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Shaping up a lineage-lessons from B lymphopoesis
Lund University.
Linköping University, Department of Clinical and Experimental Medicine, Experimental Hematology . Linköping University, Faculty of Health Sciences.
2010 (English)In: CURRENT OPINION IN IMMUNOLOGY, ISSN 0952-7915, Vol. 22, no 2, 148-153 p.Article, review/survey (Refereed) Published
Abstract [en]

Even though the development of B lymphoid cells from hematopoietic stem cells is one of the most carefully investigated models of cell differentiation in adult mammalians, a set of recent findings has to a large extent increased our understanding for how B lymphoid commitment is achieved. These include the identification of IKAROS, PU.1 and E2A as transcription factors responsible for lymphoid lineage priming in multipotent cells, as well as the identification of EBF1 dependent B lineage restricted progenitors among cells lacking expression of the classical B lineage markers CD19 or 8220. The insight that the B cell identity may be defined at an earlier stage then previously thought, allows for an increased understanding of B lymphoid development likely to unravel molecular mechanisms of high relevance also for other differentiation processes within as well as outside of the hematopoietic system.

Place, publisher, year, edition, pages
Elsevier Science B.V., Amsterdam. , 2010. Vol. 22, no 2, 148-153 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-56805DOI: 10.1016/j.coi.2010.02.001ISI: 000277811800002OAI: diva2:322257
Available from: 2010-06-04 Created: 2010-06-04 Last updated: 2010-06-04

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Sigvardsson, Mikael
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Experimental Hematology Faculty of Health Sciences
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