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GAD-alum (Diamyd) - a new concept for preservation of residual insulin secretion
Linköping University, Department of Clinical and Experimental Medicine, Pediatrics . Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Centre of Paediatrics and Gynecology and Obstetrics, Department of Paediatrics in Linköping.
2010 (English)In: EXPERT OPINION ON BIOLOGICAL THERAPY, ISSN 1471-2598, Vol. 10, no 5, 787-799 p.Article in journal (Refereed) Published
Abstract [en]

Importance of the field: Type 1 diabetes is a common and very serious disease. There has been very active research going on for a long time aiming at preservation of the residual insulin secretion by some kind of intervention to stop the destructive autoimmune process. This review covers a new type of immune intervention using auto-antigen treatment. Areas covered in this review: Immune interventions in type 1 diabetes have been tried during the last 30 years, this review mentions some of them, but the main topic is the use of the auto-antigen glutamic acid decarboxylase ( GAD) to create tolerance to stop the autoimmune process. The clinical trials have been performed during the last 15 years and are all covered. What the reader will gain: This review will give the reader a picture of the research behind treatment with GAD as an immune intervention in type 1 diabetes. Take home message: The key finding so far is that treatment with Diamyd (R) has not only been shown to preserve residual beta cell function in type 1 diabetes, but this treatment may be the proof in humans of a new concept of treating and perhaps even preventing autoimmune diseases.

Place, publisher, year, edition, pages
Ashley Publications , 2010. Vol. 10, no 5, 787-799 p.
Keyword [en]
Diamyd, GAD, GADA, immune intervention, prevention, type 1 diabetes
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-56804DOI: 10.1517/14712591003742920ISI: 000277729400011OAI: diva2:322258
Available from: 2010-06-04 Created: 2010-06-04 Last updated: 2010-06-04

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Ludvigsson, Johnny
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Pediatrics Faculty of Health SciencesDepartment of Paediatrics in Linköping
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