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Simulation of lung nodules in chest tomosynthesis
University of Gothenburg.
University of Gothenburg.
Linköping University, Department of Medicine and Health Sciences, Radiation Physics . Linköping University, Faculty of Health Sciences.
University of Gothenburg.
2010 (English)In: RADIATION PROTECTION DOSIMETRY, ISSN 0144-8420, Vol. 139, no 1-3, 130-139 p.Article in journal (Refereed) Published
Abstract [en]

The aim of the present work was to develop an adequate method for simulating lung nodules in clinical chest tomosynthesis images. Based on the visual appearance of real nodules, artificial, three-dimensional nodules with irregular shape and surface structure were created using an approach of combining spheres of different sizes and central points. The nodules were virtually positioned at the desired locations inside the patient and by using the known geometry of the tomosynthesis acquisition, the radiation emitted from the focal spot, passing through the nodule and reaching the detector could be simulated. The created nodules were thereby projected into raw-data tomosynthesis projection images before reconstruction of the tomosynthesis section images. The focal spot size, signal spread in the detector, scattered radiation, patient motion and existing anatomy at the location of the nodule were taken into account in the simulations. It was found that the blurring caused by the modulation transfer function and the patient motion overshadows the effects of a finite focal spot and aliasing and also obscures the surface structure of the nodules, which provides an opportunity to simplify the simulations and decrease the simulation times. Also, the limited in-depth resolution of the reconstructed tomosynthesis section images reduces the necessity to take details of the anatomical structures at the location of the inserted nodule into account.

Place, publisher, year, edition, pages
Oxford University Press , 2010. Vol. 139, no 1-3, 130-139 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-56793DOI: 10.1093/rpd/ncp308ISI: 000277738200023OAI: diva2:322276
Available from: 2010-06-04 Created: 2010-06-04 Last updated: 2010-06-04

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Ullman, Gustaf
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Radiation Physics Faculty of Health Sciences
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