Alternativ splicing: en process som medför att flera olika mRNA-transkript bildas från individuella gener
Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesisAlternative title
Alternative splicing: a process that leads to the formation of several different mRNA-transcripts from individual genes (English)
This review article presents the splicing process during messenger RNA maturation and how it is regulated by different Cis-regulatory RNA-sequence elements and splicing factors. A more detailed description of the process alternative splicing and its importance to the function of genes from the model organism Arabidopsis thaliana is also given. A single eukaryotic gene can by the process alternative splicing (AS) give rise to a number of functionally mature mRNA-molecules, which in turn encodes for structurally and/or functionally different proteins. During the course of evolution, the process alternative splicing has thus shown to be effective in increasing transcriptome and proteome diversity of most eukaryotic organisms. This suggests therefore that the dominant theory in molecular biology, a gene encodes for a protein, needs to be corrected. A future challenge is to determine the function of the proteins obtained from a given gene by alternative splicing.
Place, publisher, year, edition, pages
2010. , 21 p.
Alternative splicing, Arabidopsis, mRNA, proteome, RNA-splicing, transcriptome.
IdentifiersURN: urn:nbn:se:liu:diva-56880ISRN: LITH-IFM-G-EX--10/2338--SEOAI: oai:DiVA.org:liu-56880DiVA: diva2:322779
2010-05-31, BL32, Linköpings universitet, 14:35 (Swedish)
UppsokLife Earth Science
Edqvist, Johan, universitetslektor
Hargeby, Anders, universitetslektor