liu.seSearch for publications in DiVA
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
The effects of prenatal hypoxia on the levels of the α-subunits of G proteins in the heart of the Broiler chicken (Gallus gallus)
Linköping University, Department of Physics, Chemistry and Biology, Zoology .
2010 (English)Independent thesis Advanced level (degree of Master (Two Years)), 40 credits / 60 HE creditsStudent thesis
Abstract [en]

Environmental stress during embryonic development could lead to growth restriction of the embryo, and act as a risk factor for the development of cardiovascular disease in adult life. A common environmental stressor that causes growth restriction is prenatal hypoxia, which has been shown to adversely affect adult health in mammalian models. Prenatal hypoxia causes an increase in catecholamines which results in over stimulation of the cardiac β-adrenergic receptors. Previous work on chickens has shown that prenatal hypoxia causes an increase in the sensitivity of β-adrenergic receptors to epinephrine in the embryonic heart. The sensitivity of these receptors was found to be decreased in prenatal hypoxic juvenile. Prenatal hypoxia has no significant effect on the density of these receptors in neither the embryo nor the juvenile. The lack of change in receptor density implies that the effects of hypoxia are further down stream in the signalling cascade. The β2 adrenergic receptor can couple to both the stimulatory Gα subunit (Gsα) and the inhibitory Gα subunit (Giα). We hypothesized that prenatal hypoxia would cause an increase in the Gsα in the sensitized embryos, while increasing Giα in the desensitized juveniles. This study evaluated the relative levels of Gsα and Giα in the hypoxic chicken embryo, and in the prenatally hypoxic juvenile, Using western blotting. Hypoxia considerably increased Giα in the chicken embryo while having no effect on Gsα. In the prenatally hypoxic juvenile Gsα was significantly increased while no changes were found in Giα. This dissociation between the levels of Gα subunit and receptor sensitivity implies that that hypoxia affects the signaling cascade downstream of the Gα subunit.

Place, publisher, year, edition, pages
2010. , 19 p.
Keyword [en]
Beta adrenergic receptors, fetal programming, Gα protein, Hypoxia.
National Category
Natural Sciences
Identifiers
URN: urn:nbn:se:liu:diva-57191ISRN: LITH-IFM-Ex--10/2318--SEOAI: oai:DiVA.org:liu-57191DiVA: diva2:323661
Presentation
2010-05-28, Planck, Linköpings universitet, 11:35 (English)
Uppsok
Life Earth Science
Supervisors
Examiners
Available from: 2010-06-16 Created: 2010-06-11 Last updated: 2011-05-18Bibliographically approved

Open Access in DiVA

fulltext(455 kB)103 downloads
File information
File name FULLTEXT01.pdfFile size 455 kBChecksum SHA-512
d6a4bbb8cd40c4a82fbbebdfb1af98f2b9f8a8c3ee90b96c1378646066bbe5365de95747730cb804fb540471138f608b4dbeab8b078a0c8504c733df707f9b9f
Type fulltextMimetype application/pdf

Search in DiVA

By author/editor
Rashdan, Nabil
By organisation
Zoology
Natural Sciences

Search outside of DiVA

GoogleGoogle Scholar
Total: 103 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

urn-nbn

Altmetric score

urn-nbn
Total: 116 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf