Disorganised working memory functional connectivity in periodic hypersomnia
2010 (English)In: 16th Annual Meeting of the Organization for Human Brain Mapping, Barcelona 2010: 16th Annual Meeting of the Organization for Human Brain Mapping, Abstract No 1771, 2010Conference paper (Other academic)
The Kleine–Levin Syndrome (KLS) is a rare but relatively well-defined disorder characterised by excessive sleep periods (periodic hypersomnia) associated with cognitive deficits and behavioural disturbances such as binge eating and hypersexuality . The etiology of KLS is unknown and several neuroimagning methods have been applied to investigate the neural corrlates to KLS. A functional Magnetic Resonance Imaging (fMRI) study by us implicated hyperactivity in the thalamus and hypoactivity in the anterior cingulate cortex and the right anterior insula in a working memory task , which imply the involvement of a recently proposed anterior cingulate-insular control network in KLS . As we expected less coherent organisation in KLS, we compared the connectivity of the anterior cingulate-insular and thalamic (AIT) network and the well-known, working memory-related, dorsal attention network (involving the dorsolateral prefrontal cortex and parietal areas) between KLS and controls.
Place, publisher, year, edition, pages
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-57226OAI: oai:DiVA.org:liu-57226DiVA: diva2:324017