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Disorganised working memory functional connectivity in periodic hypersomnia
Linköping University. Linköping University, Faculty of Health Sciences. Linköping University, Department of Medicine and Health Sciences. Linköping University, Department of Medicine and Health Sciences, Radiology . Östergötlands Läns Landsting, Centre for Medical Imaging, Department of Radiology in Linköping.ORCID iD: 0000-0002-2167-2450
Linköping University. Linköping University, Faculty of Arts and Sciences. Linköping University, Department of Behavioural Sciences and Learning.
2010 (English)In: 16th Annual Meeting of the Organization for Human Brain Mapping, Barcelona 2010: 16th Annual Meeting of the Organization for Human Brain Mapping, Abstract No 1771, 2010Conference paper, Published paper (Other academic)
Abstract [en]

The Kleine–Levin Syndrome (KLS) is a rare but relatively well-defined disorder characterised by excessive sleep periods (periodic hypersomnia) associated with cognitive deficits and behavioural disturbances such as binge eating and hypersexuality [1]. The etiology of KLS is unknown and several neuroimagning methods have been applied to investigate the neural corrlates to KLS. A functional Magnetic Resonance Imaging (fMRI) study by us implicated hyperactivity in the thalamus and hypoactivity in the anterior cingulate cortex and the right anterior insula in a working memory task [2], which imply the involvement of a recently proposed anterior cingulate-insular control network in KLS [3]. As we expected less coherent organisation in KLS, we compared the connectivity of the anterior cingulate-insular and thalamic (AIT) network and the well-known, working memory-related, dorsal attention network (involving the dorsolateral prefrontal cortex and parietal areas) between KLS and controls.

Place, publisher, year, edition, pages
2010.
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Medical and Health Sciences
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URN: urn:nbn:se:liu:diva-57226OAI: oai:DiVA.org:liu-57226DiVA: diva2:324017
Available from: 2010-06-14 Created: 2010-06-14 Last updated: 2013-09-04

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Engström, MariaKarlsson, Thomas

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Linköping UniversityFaculty of Health SciencesDepartment of Medicine and Health SciencesRadiology Department of Radiology in LinköpingFaculty of Arts and SciencesDepartment of Behavioural Sciences and Learning
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