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Luminescence and two-photon absorption cross section of novel oligomeric luminescent conjugated polythiophenes for diagnostics of amyloid fibrils
Department of Physics, Norwegian University of Science and Technology, 7491 Trondheim, Norway.
Department of Physics, Norwegian University of Science and Technology, 7491 Trondheim, Norway.
Linköping University, Department of Physics, Chemistry and Biology, Organic Chemistry. Linköping University, The Institute of Technology.
Linköping University, Department of Physics, Chemistry and Biology, Organic Chemistry. Linköping University, Faculty of Science & Engineering.
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2010 (English)In: Nonlinear Optics Quantum Optics, ISSN 1543-0537, Vol. 40, no 1-4, 241-251 p.Article in journal (Refereed) Published
Abstract [en]

Here we present the TPA cross section and quantum efficiencies of a series of novel oligomeric luminescent conjugated polythiophenes used for detection and spectral diagnostics of amyloid protein aggregates of the amyloid-beta peptide associated with Alzheimers disease. Specifically, these probes consist of pentameric or heptameric thiophenes derivatives with carboxylic substituents attached onto various thiophene rings. The probes absorbs over a broad range approx. 400-500 nm with quantum efficiency of approx. 20% in at neutral pH conditions, and also showed TPA cross sections of 5-50 GM in the range 700-840 nm, in the same order of magnitude as commonly used fluorescein derivatives. Importantly, the multiphoton excitation capabilities of LCPs provided excellent performance when compared to imaging using conventional "single photon" excitation. It is also demonstrated their utilization in both one-and two-photon excitation laser scanning microscope spectral imaging for diagnostics of Alzheimer disease pathology in ex vivo histological sections.

Place, publisher, year, edition, pages
Old City Publishing Inc , 2010. Vol. 40, no 1-4, 241-251 p.
Keyword [en]
Amyloid detection; Amyloid spectroscopic diagnostics; Fluorescent dyes; Quantum efficiency; Thiophene oligomers; TPA cross section
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Engineering and Technology
Identifiers
URN: urn:nbn:se:liu:diva-57014OAI: oai:DiVA.org:liu-57014DiVA: diva2:324056
Available from: 2010-06-14 Created: 2010-06-09 Last updated: 2015-05-28

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Åslund, AndreasSimon, RozalynHammarström, PerNilsson, Peter

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