liu.seSearch for publications in DiVA
Change search
ReferencesLink to record
Permanent link

Direct link
Daily vegetable intake during pregnancy negatively associated to islet autoimmunity in the offspring-The ABIS study
University of Gothenburg.
Linköping University, Department of Clinical and Experimental Medicine, Pediatrics . Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Centre of Paediatrics and Gynecology and Obstetrics, Department of Paediatrics in Linköping.
2010 (English)In: PEDIATRIC DIABETES, ISSN 1399-543X, Vol. 11, no 4, 244-250 p.Article in journal (Refereed) Published
Abstract [en]

Objective: To investigate if maternal diet during pregnancy is associated with occurrence of islet autoimmunity (IA) in the offspring. Methods: Of 21 700 infants invited to the All Babies in South-east Sweden (ABIS) study, 16 004 screening questionnaires, including a 22-item food frequency questionnaire (FFQ) regarding the mothers diet during pregnancy, were completed after delivery. Follow-up of the children (questionnaires and blood sampling) was performed at 1, 2.5 and 5 yr of age. IA was defined as being positive (above the 95th percentile for healthy children) in two or more measurements of autoantibodies [glutamic acid decarboxylase (GADA); tyrosine phosphatase (IA-2A), insulin autoantibodies (IAA)] analysed at the three time points or being diagnosed with type 1 diabetes during the 5-yr follow-up period. The 5 724 children in whom we carried out two to three possible blood samplings were included in the study. Logistic regression analysis was used to identify variables predicting IA. Results: Of 5 724 children,191 (3.3%) were considered positive for IA. In a univariate analysis, less than daily consumption of vegetables (3-5 times/week) in the mothers diet was associated with increased risk of IA (OR 1.71, 95% CI:1.24-2.35, p = 0.001) compared to daily consumption (p for trend = 0.004). The association was strengthened when adjusting for known IA-risk factors (p for trend andlt; 0.001). Conclusions: Daily consumption of vegetables in the mothers diet during pregnancy was associated with a decreased risk of IA in the offspring.

Place, publisher, year, edition, pages
Blackwell Publishing Ltd , 2010. Vol. 11, no 4, 244-250 p.
Keyword [en]
autoimmunity, diet, pregnancy, type 1 diabetes
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-57389DOI: 10.1111/j.1399-5448.2009.00563.xISI: 000278196700007OAI: diva2:325562
Available from: 2010-06-18 Created: 2010-06-18 Last updated: 2010-06-18

Open Access in DiVA

No full text

Other links

Publisher's full text

Search in DiVA

By author/editor
Ludvigsson, Johnny
By organisation
Pediatrics Faculty of Health SciencesDepartment of Paediatrics in Linköping
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 134 hits
ReferencesLink to record
Permanent link

Direct link