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Daily vegetable intake during pregnancy negatively associated to islet autoimmunity in the offspring-The ABIS study
University of Gothenburg.
Linköping University, Department of Clinical and Experimental Medicine, Pediatrics . Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Centre of Paediatrics and Gynecology and Obstetrics, Department of Paediatrics in Linköping.
2010 (English)In: PEDIATRIC DIABETES, ISSN 1399-543X, Vol. 11, no 4, 244-250 p.Article in journal (Refereed) Published
Abstract [en]

Objective: To investigate if maternal diet during pregnancy is associated with occurrence of islet autoimmunity (IA) in the offspring. Methods: Of 21 700 infants invited to the All Babies in South-east Sweden (ABIS) study, 16 004 screening questionnaires, including a 22-item food frequency questionnaire (FFQ) regarding the mothers diet during pregnancy, were completed after delivery. Follow-up of the children (questionnaires and blood sampling) was performed at 1, 2.5 and 5 yr of age. IA was defined as being positive (above the 95th percentile for healthy children) in two or more measurements of autoantibodies [glutamic acid decarboxylase (GADA); tyrosine phosphatase (IA-2A), insulin autoantibodies (IAA)] analysed at the three time points or being diagnosed with type 1 diabetes during the 5-yr follow-up period. The 5 724 children in whom we carried out two to three possible blood samplings were included in the study. Logistic regression analysis was used to identify variables predicting IA. Results: Of 5 724 children,191 (3.3%) were considered positive for IA. In a univariate analysis, less than daily consumption of vegetables (3-5 times/week) in the mothers diet was associated with increased risk of IA (OR 1.71, 95% CI:1.24-2.35, p = 0.001) compared to daily consumption (p for trend = 0.004). The association was strengthened when adjusting for known IA-risk factors (p for trend andlt; 0.001). Conclusions: Daily consumption of vegetables in the mothers diet during pregnancy was associated with a decreased risk of IA in the offspring.

Place, publisher, year, edition, pages
Blackwell Publishing Ltd , 2010. Vol. 11, no 4, 244-250 p.
Keyword [en]
autoimmunity, diet, pregnancy, type 1 diabetes
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-57389DOI: 10.1111/j.1399-5448.2009.00563.xISI: 000278196700007OAI: oai:DiVA.org:liu-57389DiVA: diva2:325562
Available from: 2010-06-18 Created: 2010-06-18 Last updated: 2010-06-18

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Ludvigsson, Johnny

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