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Ion bipolar junction transistors
Linköping University, Department of Science and Technology. Linköping University, The Institute of Technology.ORCID iD: 0000-0002-9845-446X
Karolinska Institute.
Karolinska Institute.
Linköping University, Department of Science and Technology. Linköping University, The Institute of Technology.ORCID iD: 0000-0003-4791-4785
2010 (English)In: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, ISSN 0027-8424, Vol. 107, no 22, 9929-9932 p.Article in journal (Refereed) Published
Abstract [en]

Dynamic control of chemical microenvironments is essential for continued development in numerous fields of life sciences. Such control could be achieved with active chemical circuits for delivery of ions and biomolecules. As the basis for such circuitry, we report a solid-state ion bipolar junction transistor (IBJT) based on conducting polymers and thin films of anion- and cation-selective membranes. The IBJT is the ionic analogue to the conventional semiconductor BJT and is manufactured using standard microfabrication techniques. Transistor characteristics along with a model describing the principle of operation, in which an anionic base current amplifies a cationic collector current, are presented. By employing the IBJT as a bioelectronic circuit element for delivery of the neurotransmitter acetylcholine, its efficacy in modulating neuronal cell signaling is demonstrated.

Place, publisher, year, edition, pages
National Academy of Sciences; 1999 , 2010. Vol. 107, no 22, 9929-9932 p.
Keyword [en]
ionic transistor, ionic transport, conducting polymers, cell signaling
National Category
Engineering and Technology
URN: urn:nbn:se:liu:diva-57384DOI: 10.1073/pnas.0913911107ISI: 000278246000006OAI: diva2:325572
Available from: 2010-06-18 Created: 2010-06-18 Last updated: 2015-05-06
In thesis
1. Ionic Circuits for Transduction of Electronic Signals into Biological Stimuli
Open this publication in new window or tab >>Ionic Circuits for Transduction of Electronic Signals into Biological Stimuli
2012 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

Modern electronics has revolutionized the way information is processed and stored in our society. In health care and in biology it is of great interest to utilize technology to regulate physiology and to control the signaling pathways. Therefore, the coupling of electronic signals to biological functions is of great importance to many fields within the life sciences. In addition to the conventional inorganic electronics, a new branch of electronics based on organic materials has emerged during the last three decades. Some of these organic materials are very attractive for interacting with living systems since they are soft, flexible and have benevolent chemical properties.

This thesis is focused on the development of ionic circuits for transduction of electronic signals into biological stimuli. By developing such an intermediate system technology between traditional electronics and biology, signals with chemical specificity may be controlled and addressed electronically. First, a technology is described that enables direct conversion of electronic signals into ionic ones by the use biocompatible conductive polymer electrodes. The ionic bio-signals are transported in lateral channel configurations on plastic chips and precise spatiotemporal delivery of neurotransmitter, to regulate signaling in cultured neuronal cells, is demonstrated. Then, in order to achieve more advanced ionic circuit functionality, ion bipolar junction transistors were developed. These ion transistors comprise three terminals, in which a small ion current through one terminal modulates a larger ion current between the other two terminals. The devices are functional at physiological salt concentrations and are utilized to modulate neurotransmitter delivery to control Ca2+ signaling in neuronal cells. Finally, by integrating two types of transistors into the same chip, complementary NOT and NAND ion logic gates were realized for the first time. Together, the findings presented in this thesis lay the groundwork for more complex ionic circuits, such as matrix addressable delivery circuits, in which dispensing of chemical and biological signals can be directed at high spatiotemporal resolution.

Place, publisher, year, edition, pages
Linköping: Linköping University Electronic Press, 2012. 60 p.
Linköping Studies in Science and Technology. Dissertations, ISSN 0345-7524 ; 1460
National Category
Engineering and Technology
urn:nbn:se:liu:diva-80390 (URN)978-91-7519-857-6 (ISBN)
Public defence
2012-09-21, K3, Kåkenhus, Campus Norrköping, Linköpings universitet, Linköping, 11:00 (English)
Available from: 2012-08-24 Created: 2012-08-24 Last updated: 2015-05-06Bibliographically approved

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Tybrandt, KlasBerggren, Magnus
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