Synthesis of Metalloporphyrins with Oligothiophenes as Probes for Amyloid Diseases
Independent thesis Advanced level (degree of Master (Two Years)), 30 credits / 45 HE creditsStudent thesis
Abnormal aggregation of misfolded proteins is related to numerous neurodegenerative diseases, which include Alzheimer’s, Parkinson’s disease and prion diseases. Luminescent conjugated probes (LCPs) have been used as dyes for these supramolecular assemblies termed amyloid fibrils. To these probes, metalloporphyrin (MP) derivates have been attached to achieve new spectroscopic properties, which will allow for new ways to study protein aggregation diseases.
In this thesis the synthesis of two different LCPs anchored porphyrin derivates are described. The LCPs are synthesized from 3-thiopheneacetic acid and additional thiophene units are added with the use of Suzuki cross coupling reaction. The porphyrin is synthesized from pyrrol, benzaldehyde and methyl-4- formylbenzoate in a condensation reaction. In the first target molecule (TM) the porphyrin and thiophene are coupled with a spacer and the second one is a direct coupling between the two compounds.
Place, publisher, year, edition, pages
2010. , 39 p.
IdentifiersURN: urn:nbn:se:liu:diva-57989ISRN: LITH-IFM-A-Ex--10/2240--SEOAI: oai:DiVA.org:liu-57989DiVA: diva2:329838
UppsokPhysics, Chemistry, Mathematics
Åslund, AndreasÅslund, Alma