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Fatal progressive multifocal leukoencephalopathy in a patient with non-Hodgkin lymphoma treated with rituximab
Linköping University, Department of Clinical and Experimental Medicine, Infectious Diseases. Linköping University, Faculty of Health Sciences.
Linköping University, Department of Clinical and Experimental Medicine, Neurology. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Local Health Care Services in Central Östergötland, Department of Neurology.
2010 (English)In: Journal of Clinical Virology, ISSN 1386-6532, E-ISSN 1873-5967, Vol. 48, no 4, 291-293 p.Article in journal (Refereed) Published
Abstract [en]

We report a case of progressive multifocal leukoencephalopathy (PML) in a woman with non-Hodgkin lymphoma treated with chemotherapy in combination with rituximab. She presented with rapid deterioration of vision and subsequently cognitive decline. Magnetic resonance imaging (MRI) of the brain raised the suspicion of PML. The first PCR analysis of the cerebrospinal fluid (CSF) was negative, but a second sample was positive for JC virus DNA. Anti-viral treatment was ineffective and the patient died 7 months after debut of symptoms. Our case emphasizes the importance of the awareness of PML in patients with progressive neurological symptoms treated with antilymphocytic drugs and that consecutive CSF analyses may be needed to detect the JC virus.

Place, publisher, year, edition, pages
Elsevier Science B.V., Amsterdam. , 2010. Vol. 48, no 4, 291-293 p.
Keyword [en]
Leukoencephalopathy; Progressive multifocal; JC virus; Polyomavirus infections; Rituximab; Lymphoma; Non-Hodgkin
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-58189DOI: 10.1016/j.jcv.2010.05.003ISI: 000279898100015OAI: oai:DiVA.org:liu-58189DiVA: diva2:342879
Available from: 2010-08-11 Created: 2010-08-09 Last updated: 2017-12-12

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Paues, JakobVrethem, Magnus

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