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Clinical fMRI of language function in aphasic patients: Reading paradigm successful, while word generation paradigm fails
Linköping University, Department of Medical and Health Sciences, Radiology. Linköping University, Faculty of Health Sciences.ORCID iD: 0000-0002-2167-2450
Linköping University, Department of Clinical and Experimental Medicine. Linköping University, Faculty of Health Sciences.
Linköping University, Department of Clinical and Experimental Medicine. Linköping University, The Institute of Technology.
Linköping University, Department of Medical and Health Sciences, Radiology. Linköping University, Faculty of Health Sciences.
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2010 (English)In: Acta Radiologica, ISSN 0284-1851, E-ISSN 1600-0455, Vol. 51, no 6, 679-686 p.Article in journal (Refereed) Published
Abstract [en]

Background: In fMRI examinations, it is very important to select appropriate paradigms assessing the brain function of interest. In addition, the patients ability to perform the required cognitive tasks during fMRI must be taken into account. Purpose: To evaluate two language paradigms, word generation and sentence reading for their usefulness in examinations of aphasic patients and to make suggestions for improvements of clinical fMRI. Material and Methods: Five patients with aphasia after stroke or trauma sequelae were examined by fMRI. The patients language ability was screened by neurolinguistic tests and elementary pre-fMRI language tests. Results: The sentence-reading paradigm succeeded to elicit adequate language-related activation in perilesional areas whereas the word generation paradigm failed. These findings were consistent with results on the behavioral tests in that all patients showed very poor performance in phonemic fluency, but scored well above mean at a reading comprehension task. Conclusion: The sentence-reading paradigm is appropriate to assess language function in this patient group, while the word-generation paradigm seems to be inadequate. In addition, it is crucial to use elementary pre-fMRI language tests to guide the fMRI paradigm decision.

Place, publisher, year, edition, pages
Informa Healthcare , 2010. Vol. 51, no 6, 679-686 p.
Keyword [en]
fMRI; aphasia; language; word generation; sentence completion
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-58176DOI: 10.3109/02841851003753456ISI: 000280219400012OAI: oai:DiVA.org:liu-58176DiVA: diva2:342906
Note
Original Publication: Maria Engström, Marie Karlsson, Marie Crone, Mattias Ragnehed, Wolfram Antepohl, Anne-Marie Landtblom and Peter Lundberg, Clinical fMRI of language function in aphasic patients: Reading paradigm successful, while word generation paradigm fails, 2010, Acta Radiologica, (51), 6, 679-686. http://dx.doi.org/10.3109/02841851003753456 Copyright: Informa Healthcare http://informahealthcare.com/Available from: 2010-08-11 Created: 2010-08-09 Last updated: 2017-12-12

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Engström, MariaRagnehed, MattiasAntepohl, WolframLandtblom, Anne-MarieLundberg, Peter

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RadiologyFaculty of Health SciencesDepartment of Clinical and Experimental MedicineThe Institute of TechnologyRehabilitation MedicineDepartment of Rehabilitation Medicine UHLNeurologyDepartment of NeurologyDepartment of Medical Specialist
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