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A catalytic surface for amyloid fibril formation
Linköping University, Department of Physics, Chemistry and Biology, Biochemistry. Linköping University, The Institute of Technology.
Linköping University, Department of Physics, Chemistry and Biology. Linköping University, The Institute of Technology.
Linköping University, Department of Physics, Chemistry and Biology, Biochemistry. Linköping University, The Institute of Technology.
Linköping University, Department of Medicine and Health Sciences, Pharmacology . Linköping University, Faculty of Health Sciences.
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2008 (English)In: Journal of Physics, Conference Series, ISSN 1742-6588, E-ISSN 1742-6596, Vol. 100Article in journal (Refereed) Published
Abstract [en]

A hydrophobic surface incubated in a solution of protein molecules (insulin monomers) was made into a catalytic surface for amyloid fibril formation by repeatedly incubate, rinse and dry the surface. The present contribution describes how this unexpected transformation occurred and its relation to rapid fibrillation of insulin solutions in contact with the surface. A tentative model of the properties of the catalytic surface is given, corroborated by ellipsometric measurements of the thickness of the organic layer on the surface and by atomic force microscopy. The surfaces used were spontaneously oxidized silicon made hydrophobic through treatment in dichlorodimethylsilane.

Place, publisher, year, edition, pages
Institute of Physics (IoP) , 2008. Vol. 100
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Engineering and Technology
Identifiers
URN: urn:nbn:se:liu:diva-58432DOI: 10.1088/1742-6596/100/5/052039ISI: 000275655200135OAI: oai:DiVA.org:liu-58432DiVA: diva2:343186
Available from: 2010-08-12 Created: 2010-08-11 Last updated: 2017-12-12

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Hammarström, PerAli Malik, MuhammadMishra, RajeshSvensson, SamuelTengvall, PenttiLundström, Ingemar

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Hammarström, PerAli Malik, MuhammadMishra, RajeshSvensson, SamuelTengvall, PenttiLundström, Ingemar
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BiochemistryThe Institute of TechnologyDepartment of Physics, Chemistry and BiologyPharmacology Faculty of Health SciencesApplied Physics
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Journal of Physics, Conference Series
Engineering and Technology

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