A catalytic surface for amyloid fibril formation
2008 (English)In: Journal of Physics, Conference Series, ISSN 1742-6588, E-ISSN 1742-6596, Vol. 100Article in journal (Refereed) Published
A hydrophobic surface incubated in a solution of protein molecules (insulin monomers) was made into a catalytic surface for amyloid fibril formation by repeatedly incubate, rinse and dry the surface. The present contribution describes how this unexpected transformation occurred and its relation to rapid fibrillation of insulin solutions in contact with the surface. A tentative model of the properties of the catalytic surface is given, corroborated by ellipsometric measurements of the thickness of the organic layer on the surface and by atomic force microscopy. The surfaces used were spontaneously oxidized silicon made hydrophobic through treatment in dichlorodimethylsilane.
Place, publisher, year, edition, pages
Institute of Physics (IoP) , 2008. Vol. 100
Engineering and Technology
IdentifiersURN: urn:nbn:se:liu:diva-58432DOI: 10.1088/1742-6596/100/5/052039ISI: 000275655200135OAI: oai:DiVA.org:liu-58432DiVA: diva2:343186