Intra- and inter-individual variability in the development of erythema after application of methyl nicotinate evaluated by polarization spectroscopy imaging
2010 (English)In: JOURNAL OF PHARMACY AND PHARMACOLOGY, vol 62, issue 6, pp 801-801, ISSN: 002-3573, Pharmaceutical Press , 2010, Vol. 62, no 6, 801-801 p.Conference paper (Refereed)
The concept that the time to onset of erythema after the application of the rubefacient and urticant substance methyl nicotinate (MN) indicates skin barrier competence was introduced 30 years ago. MN produces a dose-dependent erythema on topical application to intact skin, the nature of which is known to be fast moving (in the order of minutes) and variable. Using tissue viability imaging (TiVi) the time course and degree of the reaction can be conveniently followed and analysed. Inter-individual variability can be quite marked but intra-individual variability is less pronounced. At the upper end of provocation (higher doses, more sensitive individuals) urtication can occur, which decreases blood flow by increasing pressure on and thus emptying capillaries. The TiVi system can quantitate urtication and inherent (blanched) skin colour. The utility of MN application in the study of individual barrier function and microvascular reactivity is increased by the use of the TiVi system for collection and analysis of data.
Place, publisher, year, edition, pages
Pharmaceutical Press , 2010. Vol. 62, no 6, 801-801 p.
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-58366DOI: 10.1211/jpp.62.06.0016ISI: 000278527300063OAI: oai:DiVA.org:liu-58366DiVA: diva2:343321
Perspectives in Percutaneous Penetration, 12th International Conference, La Grande Motte, France