liu.seSearch for publications in DiVA
Change search
ReferencesLink to record
Permanent link

Direct link
The intestinal barrier and its regulation by neuroimmune factors
Linköping University, Department of Clinical and Experimental Medicine, Surgery. Linköping University, Faculty of Health Sciences.
Linköping University, Department of Clinical and Experimental Medicine, Surgery. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Centre of Surgery and Oncology, Department of Surgery in Östergötland.
2010 (English)In: Neurogastroenterology and Motility, ISSN 1350-1925, E-ISSN 1365-2982, Vol. 22, no 7, 718-733 p.Article, review/survey (Refereed) Published
Abstract [en]

Background The ability to control uptake across the mucosa and protect from damage of harmful substances from the lumen is defined as intestinal barrier function. A disturbed barrier dysfunction has been described in many human diseases and animal models, for example, inflammatory bowel disease, irritable bowel syndrome, and intestinal hypersensitivity. In most diseases and models, alterations are seen both of the paracellular pathway, via the tight junctions, and of the transcellular routes, via different types of endocytosis. Recent studies of pathogenic mechanisms have demonstrated the important role of neuroimmune interaction with the epithelial cells in the regulation of barrier function. Neural impulses from extrinsic vagal and/or sympathetic efferent fibers or intrinsic enteric nerves influence mucosal barrier function via direct effects on epithelial cells or via interaction with immune cells. For example, by nerve-mediated activation by corticotropin-releasing hormone or cholinergic pathways, mucosal mast cells release a range of mediators with effects on transcellular, and/or paracellular permeability (for example, tryptase, TNF-alpha, nerve growth factor, and interleukins). Purpose In this review, we discuss current physiological and pathophysiological aspects of the intestinal barrier and, in particular, its regulation by neuroimmune factors.

Place, publisher, year, edition, pages
Blackwell Publishing Ltd , 2010. Vol. 22, no 7, 718-733 p.
Keyword [en]
corticotropin-releasing hormone; enteric nerves; mast cell; permeability; stress
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-58363DOI: 10.1111/j.1365-2982.2010.01498.xISI: 000278525200002OAI: diva2:343330
Available from: 2010-08-13 Created: 2010-08-11 Last updated: 2014-10-01

Open Access in DiVA

No full text

Other links

Publisher's full text

Search in DiVA

By author/editor
Keita, Åsa V.Söderholm, Johan D
By organisation
SurgeryFaculty of Health SciencesDepartment of Surgery in Östergötland
In the same journal
Neurogastroenterology and Motility
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 56 hits
ReferencesLink to record
Permanent link

Direct link