How Should Thiopurine Treatment be Monitored? Methodological Aspects
2010 (English)In: Nucleosides, Nucleotides & Nucleic Acids, ISSN 1525-7770, E-ISSN 1532-2335, Vol. 29, no 04-Jun, 278-283 p.Article in journal (Refereed) Published
Monitoring of thiopurine metabolites is important due to a complex metabolism with large interindividual variation, but the suitability of currently used methods has been questioned. The drawbacks include poor reproducibility, the inability to differentiate between the different analytes, as well as the use of a nontarget matrix. Further research should be directed toward measuring thiopurine metabolites in mononuclear cells, measuring the different nucleotides specifically, as well as measuring the incorporation of thioguanine into DNA. The studies should not be limited to thioguanosine nucleotides but include methylthioinosine nucleotides as well.
Place, publisher, year, edition, pages
Taylor and Francis , 2010. Vol. 29, no 04-Jun, 278-283 p.
TGN; methylthioinosine monophosphate; methyl mercaptopurine; inflammatory bowel disease; childhood leukemia
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-58361DOI: 10.1080/15257771003741133ISI: 000278713200004OAI: oai:DiVA.org:liu-58361DiVA: diva2:343334
This is an electronic version of an article published in:
Svante Vikingsson, Björn Carlsson, Sven Almer and Curt Peterson, How Should Thiopurine Treatment be Monitored? Methodological Aspects, 2010, Nucleosides, Nucleotides & Nucleic Acids, (29), 04-Jun, 278-283.
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