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How Should Thiopurine Treatment be Monitored? Methodological Aspects
Linköping University, Department of Medicine and Health Sciences, Clinical Pharmacology. Linköping University, Faculty of Health Sciences.
Linköping University, Department of Medicine and Health Sciences, Clinical Pharmacology. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Centre for Laboratory Medicine, Department of Clinical Pharmacology.
Linköping University, Department of Clinical and Experimental Medicine, Gastroenterology and Hepatology. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Centre for Medicine, Department of Endocrinology and Gastroenterology UHL.
Linköping University, Department of Medicine and Health Sciences, Clinical Pharmacology. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Centre of Surgery and Oncology, Department of Oncology UHL.
2010 (English)In: Nucleosides, Nucleotides & Nucleic Acids, ISSN 1525-7770, E-ISSN 1532-2335, Vol. 29, no 04-Jun, 278-283 p.Article in journal (Refereed) Published
Abstract [en]

Monitoring of thiopurine metabolites is important due to a complex metabolism with large interindividual variation, but the suitability of currently used methods has been questioned. The drawbacks include poor reproducibility, the inability to differentiate between the different analytes, as well as the use of a nontarget matrix. Further research should be directed toward measuring thiopurine metabolites in mononuclear cells, measuring the different nucleotides specifically, as well as measuring the incorporation of thioguanine into DNA. The studies should not be limited to thioguanosine nucleotides but include methylthioinosine nucleotides as well.

Place, publisher, year, edition, pages
Taylor and Francis , 2010. Vol. 29, no 04-Jun, 278-283 p.
Keyword [en]
TGN; methylthioinosine monophosphate; methyl mercaptopurine; inflammatory bowel disease; childhood leukemia
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-58361DOI: 10.1080/15257771003741133ISI: 000278713200004OAI: oai:DiVA.org:liu-58361DiVA: diva2:343334
Note
This is an electronic version of an article published in: Svante Vikingsson, Björn Carlsson, Sven Almer and Curt Peterson, How Should Thiopurine Treatment be Monitored? Methodological Aspects, 2010, Nucleosides, Nucleotides & Nucleic Acids, (29), 04-Jun, 278-283. Nucleosides, Nucleotides & Nucleic Acids is available online at informaworldTM: http://dx.doi.org/10.1080/15257771003741133 Copyright: Taylor & Francis http://www.tandf.co.uk/journals/default.asp Available from: 2010-08-13 Created: 2010-08-11 Last updated: 2011-03-18Bibliographically approved

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Vikingsson, SvanteCarlsson, BjörnAlmer, SvenPeterson, Curt

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Clinical PharmacologyFaculty of Health SciencesDepartment of Clinical PharmacologyGastroenterology and HepatologyDepartment of Endocrinology and Gastroenterology UHLDepartment of Oncology UHL
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