Novel Strategies in the Thiopurine Treatment of Inflammatory Bowel Disease
2010 (English)In: Nucleosides, Nucleotides & Nucleic Acids, ISSN 1525-7770, E-ISSN 1532-2335, Vol. 29, no 04-Jun, 267-277 p.Article in journal (Refereed) Published
Thiopurine drugs are widely used as immunomodulatory and corticosteroid-sparing agents in inflammatory bowel disease. Despite being old drugs, a renewed research and clinical interest in their application has emerged during the last decade. The application of pharmacogenetic insights and metabolic monitoring, together with treatment strategies in combination with anti-TNF-antibodies and possibilities to modulate their metabolism, has paved the way to a omoderno use of the thiopurines. These aspects are briefly overviewed herein.
Place, publisher, year, edition, pages
Taylor and Francis , 2010. Vol. 29, no 04-Jun, 267-277 p.
Thiopurines; inflammatory bowel disease; Crohns disease; ulcerative colitis; treatment strategies
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-58360DOI: 10.1080/15257771003729559ISI: 000278713200003OAI: oai:DiVA.org:liu-58360DiVA: diva2:343335