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Novel Strategies in the Thiopurine Treatment of Inflammatory Bowel Disease
Linköping University, Department of Clinical and Experimental Medicine, Gastroenterology and Hepatology . Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Centre for Medicine, Department of Endocrinology and Gastroenterology UHL.
2010 (English)In: Nucleosides, Nucleotides & Nucleic Acids, ISSN 1525-7770, E-ISSN 1532-2335, Vol. 29, no 04-Jun, 267-277 p.Article in journal (Refereed) Published
Abstract [en]

Thiopurine drugs are widely used as immunomodulatory and corticosteroid-sparing agents in inflammatory bowel disease. Despite being old drugs, a renewed research and clinical interest in their application has emerged during the last decade. The application of pharmacogenetic insights and metabolic monitoring, together with treatment strategies in combination with anti-TNF-antibodies and possibilities to modulate their metabolism, has paved the way to a omoderno use of the thiopurines. These aspects are briefly overviewed herein.

Place, publisher, year, edition, pages
Taylor and Francis , 2010. Vol. 29, no 04-Jun, 267-277 p.
Keyword [en]
Thiopurines; inflammatory bowel disease; Crohns disease; ulcerative colitis; treatment strategies
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-58360DOI: 10.1080/15257771003729559ISI: 000278713200003OAI: diva2:343335
Available from: 2010-08-13 Created: 2010-08-11 Last updated: 2010-08-13

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Almer, Sven
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Gastroenterology and Hepatology Faculty of Health SciencesDepartment of Endocrinology and Gastroenterology UHL
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Nucleosides, Nucleotides & Nucleic Acids
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ReferencesLink to record
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