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A global network of transcription factors, involving E2A, EBF1 and Foxo1, that orchestrates B cell fate
University of California San Diego.
University of California San Diego.
University of California San Diego.
University of California San Diego.
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2010 (English)In: Nature Immunology, ISSN 1529-2908, Vol. 11, no 7, 635-U109 p.Article in journal (Refereed) Published
Abstract [en]

It is now established that the transcription factors E2A, EBF1 and Foxo1 have critical roles in B cell development. Here we show that E2A and EBF1 bound regulatory elements present in the Foxo1 locus. E2A and EBF1, as well as E2A and Foxo1, in turn, were wired together by a vast spectrum of cis-regulatory sequences. These associations were dynamic during developmental progression. Occupancy by the E2A isoform E47 directly resulted in greater abundance, as well as a pattern of monomethylation of histone H3 at lysine 4 (H3K4) across putative enhancer regions. Finally, we divided the pro-B cell epigenome into clusters of loci with occupancy by E2A, EBF and Foxo1. From this analysis we constructed a global network consisting of transcriptional regulators, signaling and survival factors that we propose orchestrates B cell fate.

Place, publisher, year, edition, pages
Nature Publishing Group , 2010. Vol. 11, no 7, 635-U109 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-58343DOI: 10.1038/ni.1891ISI: 000278926400020OAI: diva2:343364
Available from: 2010-08-13 Created: 2010-08-11 Last updated: 2010-08-13

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Sigvardsson, Mikael
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Experimental Hematology Faculty of Health Sciences
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