Volume Kinetics for Infusion Fluids
2010 (English)In: Anesthesiology, ISSN 0003-3022, E-ISSN 1528-1175, Vol. 113, no 2, 470-481 p.Article, review/survey (Refereed) Published
Volume kinetics is a method for analyzing and simulating the distribution and elimination of infusion fluids. Approximately 50 studies describe the disposition of 0.9% saline, acetated and lactated Ringer´s solution, based on repeated measurements of the hemoglobin concentration and (sometimes) the urinary excretion.
The slow distribution to the peripheral compartment results in a 50-75% larger plasma dilution during an infusion of crystalloid fluid than would be expected if distribution had been immediate. A drop in the arterial pressure during induction of anesthesia reduces the rate of distribution even further.
The renal clearance of the infused fluid during surgery is only 10-20% compared to conscious volunteers. Some of this temporary decrease can be attributed to the anesthesia and probably also to preoperative psychological stress and/or dehydration.
Crystalloid fluid might be allocated to “non-functional” fluid spaces where it is unavailable for excretion. This amounts to approximately 20-25% during minor (thyroid) surgery.
Place, publisher, year, edition, pages
Lippincott Williams andamp; Wilkins; 1999 , 2010. Vol. 113, no 2, 470-481 p.
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-58537DOI: 10.1097/ALN.0b013e3181dcd88fISI: 000280363900028OAI: oai:DiVA.org:liu-58537DiVA: diva2:343392