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Volume Kinetics for Infusion Fluids
Östergötlands Läns Landsting, Anaesthesiology and Surgical Centre, Department of Anaesthesiology and Intensive Care VHN. Linköping University, Faculty of Health Sciences. Linköping University, Department of Medical and Health Sciences, Anesthesiology.
2010 (English)In: Anesthesiology, ISSN 0003-3022, E-ISSN 1528-1175, Vol. 113, no 2, 470-481 p.Article, review/survey (Refereed) Published
Abstract [en]

Volume kinetics is a method for analyzing and simulating the distribution and elimination of infusion fluids. Approximately 50 studies describe the disposition of 0.9% saline, acetated and lactated Ringer´s solution, based on repeated measurements of the hemoglobin concentration and (sometimes) the urinary excretion.

The slow distribution to the peripheral compartment results in a 50-75% larger plasma dilution during an infusion of crystalloid fluid than would be expected if distribution had been immediate. A drop in the arterial pressure during induction of anesthesia reduces the rate of distribution even further.

The renal clearance of the infused fluid during surgery is only 10-20% compared to conscious volunteers. Some of this temporary decrease can be attributed to the anesthesia and probably also to preoperative psychological stress and/or dehydration. 

Crystalloid fluid might be allocated to “non-functional” fluid spaces where it is unavailable for excretion. This amounts to approximately 20-25% during minor (thyroid) surgery.

Place, publisher, year, edition, pages
Lippincott Williams andamp; Wilkins; 1999 , 2010. Vol. 113, no 2, 470-481 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-58537DOI: 10.1097/ALN.0b013e3181dcd88fISI: 000280363900028OAI: diva2:343392
Available from: 2013-04-22 Created: 2010-08-13 Last updated: 2013-04-22Bibliographically approved

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