Neuroborreliosis-an epidemiological, clinical and healthcare cost study from an endemic area in the south-east of Sweden
2010 (English)In: Clinical Microbiology and Infection, ISSN 1198-743X, E-ISSN 1469-0691, Vol. 16, no 8, 1245-1251 p.Article in journal (Refereed) Published
We studied retrospectively the medical records of all patients (n = 150) diagnosed, by cerebrospinal fluid (CSF) analysis, with neuroborreliosis (NB) in Jonkoping County, Sweden during 2000-2005. The number of NB cases increased from 5/100 000 to 10/100 000 inhabitants/year. In 17% of the patients, anti-Borrelia antibodies were found in CSF but not in serum at the time of diagnosis. Facial palsy, headache and fever were frequent manifestations in children, whereas unspecific muscle and joint pain were the most commonly reported symptoms in older patients. Post-treatment symptoms persisting for more than 6 months occurred in 13%, and the patients concerned were significantly older, had longer-lasting symptoms prior to treatment, had higher levels of Borrelia-specific IgG in CSF, and more often had radiculitis. The total cost of NB-related healthcare was estimated to be euro500 000 for the entire study group (euro3300 per patient), and the cost of social benefits was estimated to be euro134 000 (euro2000 per patient). CSF analysis is necessary for the diagnosis of NB, because some patients develop antibodies in serum later than in CSF. Early diagnosis of borreliosis would result in reduced human suffering and in economic gain.
Place, publisher, year, edition, pages
Blackwell Publishing Ltd , 2010. Vol. 16, no 8, 1245-1251 p.
Clinical, epidemiology, healthcare economy, Lyme disease, neuroborreliosis
National CategoryInfectious Medicine
IdentifiersURN: urn:nbn:se:liu:diva-58536DOI: 10.1111/j.1469-0691.2009.03059.xISI: 000280359900034OAI: oai:DiVA.org:liu-58536DiVA: diva2:343393
This is the pre-reviewed version of the following article:
A J Henningsson, Bo-Eric Malmvall, Jan Ernerudh, A Matussek and Pia Forsberg, Neuroborreliosis-an epidemiological, clinical and healthcare cost study from an endemic area in the south-east of Sweden, 2010, CLINICAL MICROBIOLOGY AND INFECTION, (16), 8, 1245-1251.
which has been published in final form at:
Copyright: Blackwell Publishing Ltd