liu.seSearch for publications in DiVA
Change search
ReferencesLink to record
Permanent link

Direct link
Medication in Relation to ST-Segment Elevation Myocardial Infarction in Patients With a First Myocardial Infarction Swedish Register of Information and Knowledge About Swedish Heart Intensive Care Admissions (RIKS-HIA)
Sahlgrenska University Hospital.
Uppsala Clinical Research Centre.
Linköping University, Department of Medicine and Health Sciences, Cardiology . Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Heart Centre, Department of Cardiology.
Sahlgrenska University Hospital.
Show others and affiliations
2010 (English)In: ARCHIVES OF INTERNAL MEDICINE, ISSN 0003-9926, Vol. 170, no 15, 1375-1381 p.Article in journal (Refereed) Published
Abstract [en]

Background: The extent and the severity of acute myocardial infarction (MI) is decreasing. Out-of-hospital medical management before the hospital admission could alter clinical presentation in acute MI. We used a large national patient register to investigate the relation between previous medication use (aspirin, beta-blockers, angiotensin-converting enzyme [ACE] inhibitors, and statins) and the risk of presenting with ST-segment elevation MI (STEMI) or non-STEMI. Methods: We included 103 459 consecutive patients from the Swedish Register of Information and Knowledge About Swedish Heart Intensive Care Admissions (RIKS-HIA) admitted between January 1, 1996, and December 31, 2006, with a first acute MI. Results: The patients with STEMI (43.5% of the total) were younger, had less prior cardiovascular disease, and used fewer medications before hospitalization. Of the STEMI patients, 61.4% had used no medication vs 45.9% of the patients with non-STEMI. After multiple adjustments, use of aspirin, beta-blockers, ACE inhibitors, and statins before hospitalization were all associated with substantially lower odds of presenting with STEMI. Furthermore, the risk decreased with the number of previous medications, and the use of 3 or more medications was associated with a multiply adjusted odds ratio of presenting with STEMI of 0.48 (99% confidence interval, 0.44-0.52) compared with no medications at admission. Conclusions: Use of aspirin, beta-blockers, ACE inhibitors, or statins before hospital admission in patients with a first acute MI is associated with substantially less risk of presenting with STEMI. The risk decreases with the increasing number of these medications used before acute MI, underlining the benefit of preventive medication in high-risk patients.

Place, publisher, year, edition, pages
Ama American Medical Association , 2010. Vol. 170, no 15, 1375-1381 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-58659DOI: 10.1001/archinternmed.2010.203ISI: 000280651500014PubMedID: 20696964OAI: diva2:344875
Available from: 2010-08-22 Created: 2010-08-20 Last updated: 2010-09-03

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Stenestrand, Ulf
By organisation
Cardiology Faculty of Health SciencesDepartment of Cardiology
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 30 hits
ReferencesLink to record
Permanent link

Direct link