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Cancer Risk in Children and Young Adults Conceived by In Vitro Fertilization
Lund University.
Linköping University, Department of Clinical and Experimental Medicine, Pediatrics . Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Centre of Paediatrics and Gynecology and Obstetrics, Department of Paediatrics in Linköping.
National Board of Health and Welfare, Stockholm, Sweden .
National Board of Health and Welfare, Stockholm, Sweden .
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2010 (English)In: PEDIATRICS, ISSN 0031-4005, Vol. 126, no 2, E270-E276 p.Article in journal (Refereed) Published
Abstract [en]

OBJECTIVES: Studies conducted so far have found no statistically significant increased risk for cancer among children who are born after in vitro fertilization (IVF). METHODS: We followed 26 692 children who were born after IVF during the years 1982-2005 by using the Swedish Cancer Register and compared the number of children who had cancer and were born after IVF with children who were not conceived by IVF. Adjustment was made for year of birth. RESULTS: Maternal age, parity, smoking, subfertility, previous miscarriages, BMI, and multiple births did not significantly affect cancer risk in offspring. High birth weight, premature delivery, and the presence of respiratory diagnoses and low Apgar score were risk factors for cancer. We identified 53 cases of cancer in children who were born after IVF against 38 expected cases: 18 of them with hematologic cancer (15 of them acute lymphoblastic leukemia), 17 with eye or central nervous system tumors, and 12 with other solid cancers. There were 6 cases of Langerhans histiocytosis against 1.0 expected. The total cancer risk estimate was 1.42 (95% confidence interval: 1.09-1.87). CONCLUSIONS: We found a moderately increased risk for cancer in children who were conceived by IVF. Putative intermediary factors could be preterm birth and neonatal asphyxia.

Place, publisher, year, edition, pages
American Academy of Pediatrics; 1999 , 2010. Vol. 126, no 2, E270-E276 p.
Keyword [en]
childhood cancer, histiocytosis, in vitro fertilization, leukemia, brain tumor
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-58643DOI: 10.1542/peds.2009-3225ISI: 000280565700012OAI: diva2:344891
Available from: 2010-08-22 Created: 2010-08-20 Last updated: 2010-08-22

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Finnström, Orvar
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Pediatrics Faculty of Health SciencesDepartment of Paediatrics in Linköping
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