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Cholecystokinin in plasma and cerebrospinal fluid-A study in healthy young women
Linköping University, Department of Clinical and Experimental Medicine, Clinical Chemistry. Linköping University, Faculty of Health Sciences.
Linköping University, Department of Clinical and Experimental Medicine, Clinical Chemistry. Linköping University, Faculty of Health Sciences.
Linköping University, Department of Clinical and Experimental Medicine, Clinical Chemistry. Linköping University, Faculty of Health Sciences.
Linköping University, Department of Clinical and Experimental Medicine, Clinical Chemistry. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Centre for Laboratory Medicine, Department of Clinical Chemistry.
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2010 (English)In: PEPTIDES, ISSN 0196-9781, Vol. 31, no 8, 1625-1628 p.Article in journal (Refereed) Published
Abstract [en]

Cholecystokinin (CCK) is widely distributed in the brain and is known to affect behavioral and physiological functions including anxiety and pain. The expression of CCK has been shown to be regulated by estrogen and to vary during the estrous cycle in rat brain. In the present study CCK was determined in plasma from 25 healthy women (age 25.0 +/- 3.5) during the menstrual cycle, in the late luteal phase and in the follicular phase. In the follicular phase, a lumbar puncture was performed at the same time that a plasma sample was taken in 15 subjects. The participants had fasted and were nicotine-free for at least 8 h preceding the sampling. We compared CCK-like immunoreactivity (CCK-LI) in plasma from 25 subjects in the late luteal phase (LLP) and the follicular phase (FP) and found that there was no difference during the menstrual cycle (n-25, R-2 =89.60%, p = n.s.). In the follicular phase no significant difference was found between CCK-LI in plasma and in cerebrospinal fluid (CSF) collected at the same time (n =15, R-2 = 55.32%, p = n.s.).

Place, publisher, year, edition, pages
Elsevier Science B.V., Amsterdam. , 2010. Vol. 31, no 8, 1625-1628 p.
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Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-58776DOI: 10.1016/j.peptides.2010.04.028ISI: 000280663600028OAI: oai:DiVA.org:liu-58776DiVA: diva2:345785
Note
Original Publication: Kristina Lundberg, Susanne Hilke, Conny Nordin, Elvar Theodorsson and Ann Josefsson, Cholecystokinin in plasma and cerebrospinal fluid-A study in healthy young women, 2010, PEPTIDES, (31), 8, 1625-1628. http://dx.doi.org/10.1016/j.peptides.2010.04.028 Copyright: Elsevier Science B.V., Amsterdam. http://www.elsevier.com/ Available from: 2010-08-27 Created: 2010-08-27 Last updated: 2010-09-02

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Hilke, SusanneTheodorsson, ElvarJosefsson, Ann

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Clinical ChemistryFaculty of Health SciencesDepartment of Clinical ChemistryObstetrics and gynecology Department of Gynecology and Obstetrics in Linköping
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