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Liquid chromatography/tandem mass spectrometry method for determination of olanzapine and N-desmethylolanzapine in human serum and cerebrospinal fluid
Linköping University, Department of Physics, Chemistry and Biology. Linköping University, The Institute of Technology. (Department of Forensic Genetics and Forensic Toxicology, National Board of Forensic Medicine, SE-58133 Linköping, Sweden)
National Board of Forensic Medicine, Linköping.
Linköping University, Department of Clinical and Experimental Medicine, Psychiatry . Linköping University, Faculty of Health Sciences.
University Hospital, Uppsala.
2010 (English)In: Journal of Pharmaceutical and Biomedical Analysis, ISSN 0731-7085, E-ISSN 1873-264X, Vol. 53, no 3, 576-582 p.Article in journal (Refereed) Published
Abstract [en]

A validated, accurate and sensitive LC-MS/MS method for determination of olanzapine and its metabolite N-desmethylolanzapine has been developed. The analytes were quantified by tandem mass spectrometry operating in positive electrospray ionization mode with multiple reaction monitoring. Olanzapine and desmethylolanzapine were extracted from serum or cerebral spinal fluid samples, 200 microl, with tert-butyl methyl ether using olanzapine-D3 as internal standard. Calibrations for olanzapine and desmethylolanzapine were linear within the selected range of 0.2-30 ng/ml (6-96 nM) in cerebral spinal fluid and for olanzapine in plasma, in the range of 5-100 ng/ml (16-320 nM). The method was successfully used for the analysis of samples from patients treated with olanzapine in the dose range of 2.5-25mg/day.

Place, publisher, year, edition, pages
2010. Vol. 53, no 3, 576-582 p.
Keyword [en]
Olanzapine; N-desmetylolanzapine; Serum; Cerebrospinal fluid; Tandem mass spectrometry; LC–MS/MS
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-58802DOI: 10.1016/j.jpba.2010.03.040PubMedID: 20452161OAI: oai:DiVA.org:liu-58802DiVA: diva2:345815
Available from: 2010-08-27 Created: 2010-08-27 Last updated: 2017-12-12

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Josefsson, MartinSkogh, Elisabeth

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