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Immune intervention in children with type 1 diabetes
Linköping University, Department of Clinical and Experimental Medicine, Pediatrics . Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Centre of Paediatrics and Gynecology and Obstetrics, Department of Paediatrics in Linköping.
2010 (English)In: Current Diabetes Reports, ISSN 1534-4827, Vol. 10, no 5, 370-379 p.Article in journal (Refereed) Published
Abstract [en]

Not only T cells but also B cells play a role in the autoimmune process. Both monoclonal antiCD3 and antiCD20 antibodies seem efficacious. However, such treatments need to be refined to minimize adverse events. Use of autoantigens to create tolerance is a concept with great potential. GAD65 treatment has shown efficacy without adverse events thus far, and administration of the insulin B chain shows interesting immunologic effects. Other more or less speculative approaches to modulate the immune process need further studies with good design. Risks that are too serious cannot be motivated. In addition, as the beta cells may die even though the autoimmune process is stopped, protective measures may be valuable (eg, active insulin treatment, and perhaps interleukin-1 receptor antagonists to reduce the nonautoimmune inflammation). Combination of immune intervention, protection of the beta cells, and stimulation of regeneration may lead to a milder disease or even a cure in the future, and prevention is no longer unrealistic.

Place, publisher, year, edition, pages
2010. Vol. 10, no 5, 370-379 p.
Keyword [en]
Type 1 diabetes, Immune intervention, AntiCD3, AntiCD20, GAD65, Autoantigens, Vitamin D, β-Cell regeneration, Children
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-58817DOI: 10.1007/s11892-010-0138-yOAI: diva2:345864
Available from: 2010-08-27 Created: 2010-08-27 Last updated: 2010-08-27

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Ludvigsson, Johnny
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Pediatrics Faculty of Health SciencesDepartment of Paediatrics in Linköping
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