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Fluid pressure and flow as a cause of bone resorption
Linköping University, Department of Clinical and Experimental Medicine, Orthopaedics and Sports Medicine. Linköping University, Faculty of Health Sciences.
Hospital for Special Surgery, New York, NY, USA.
Hospital for Special Surgery, New York, NY, USA.
Linköping University, Department of Management and Engineering, Mechanics . Linköping University, The Institute of Technology.
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2010 (English)In: Acta Orthopaedica, ISSN 1745-3674, E-ISSN 1745-3682, Vol. 81, no 4, 508-516 p.Article in journal (Refereed) Published
Abstract [en]

Background Unstable implants in bone become surrounded by an osteolytic zone. This is seen around loose screws, for example, but may also contribute to prosthetic loosening. Previous animal studies have shown that such zones can be induced by fluctuations in fluid pressure or flow, caused by implant instability. Method To understand the roles of pressure and flow, we describe the 3-dimensional distribution of osteolytic lesions in response to fluid pressure and flow in a previously reported rat model of aseptic loosening. 50 rats had a piston inserted in the proximal tibia, designed to produce 20 local spikes in fluid pressure of a clinically relevant magnitude (700 mmHg) twice a day. The spikes lasted for about 0.3 seconds. After 2 weeks, the pressure was measured in vivo, and the osteolytic lesions induced were studied using micro-CT scans. Results Most bone resorption occurred at pre-existing cavities within the bone in the periphery around the pressurized region, and not under the piston. This region is likely to have a higher fluid flow and less pressure than the area just beneath the piston. The velocity of fluid flow was estimated to be very high (roughly 20 mm/s). Interpretation The localization of the resorptive lesions suggests that high-velocity fluid flow is important for bone resorption induced by instability.

Place, publisher, year, edition, pages
2010. Vol. 81, no 4, 508-516 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-58811DOI: 10.3109/17453674.2010.504610OAI: diva2:346649
Available from: 2010-09-02 Created: 2010-08-27 Last updated: 2010-09-02

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Fahlgren, AnnaBostrom, Mathias PgYang, XuJohansson, LarsEdlund, UlfAgholme, FredrikAspenberg, Per
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Orthopaedics and Sports MedicineFaculty of Health SciencesMechanics The Institute of TechnologyDepartment of Orthopaedics Linköping
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Acta Orthopaedica
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