liu.seSearch for publications in DiVA
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Complex Biphasic Changes of Neuropeptide Concentrations in the Rat Limbic System During Pregnancy and Parturition
Linköping University, Department of Clinical and Experimental Medicine, Obstetrics and gynecology . Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Centre of Paediatrics and Gynecology and Obstetrics, Department of Gynecology and Obstetrics in Linköping.
Linköping University, Department of Clinical and Experimental Medicine, Clinical Chemistry. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Centre for Laboratory Medicine, Department of Clinical Chemistry.
Linköping University, Department of Clinical and Experimental Medicine, Obstetrics and gynecology . Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Centre of Paediatrics and Gynecology and Obstetrics, Department of Gynecology and Obstetrics in Linköping.
Linköping University, Department of Clinical and Experimental Medicine, Obstetrics and gynecology . Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Centre of Paediatrics and Gynecology and Obstetrics, Department of Gynecology and Obstetrics in Linköping.
Show others and affiliations
2010 (English)In: The Open Neuroendocrinology Journal, ISSN 1876-5289, Vol. 3, 45-51 p.Article in journal (Refereed) Published
Abstract [en]

Sex hormones including estrogens affect brain areas involved in mood and cognition in addition to directly controlling reproduction and reproductive behavior. We studied the effect of pregnancy and puerperium on the concentrations of cholecystokinin (CCK), neuropeptide Y (NPY), substance P (SP) and galanin in tissue extracts from the rat striatum, frontal cortex and the hippocampal formation by means of radioimmunoassay. The most profound effects were found in the frontal cortex. Thus, cholecystokinin-like immunoreactivity (CCK-LI) was increased by 40 % during late pregnancy (p < 0.01) compared to estrous whereas SP-LI and galanin-LI decreased 25 % and 10 %, respectively. Postpartum, CCKLI decreased by 26% compared to pregnancy (p < 0.05) whereas SP-LI and galanin-LI were increased to a level above estrous (SP, P < 0.01; galanin, P < 0.05). No significant effect was observed in NPY-LI in this area. In the striatum during late pregnancy the concentrations of cholecystokinin-LI increased by 29 % (p < 0.05), NPY-LI by 22% (p < 0.05) whereas SP-LI slightly increased (not significant). Postpartum, cholecystokinin-LI decreased by 25 % (p < 0.01) compared to pregnancy and NPY by 16 % (p < 0.01). SP continued to increase postpartum by 33 % (p < 0.05) whereas no effect was observed on galanin-LI concentration. Surprisingly, we did not observe any changes in any peptide or groups measured in the hippocampal formation. The complex hormonal adjustments occurring during pregnancy and in the puerperium induce profound changes in the concentrations of several neuropeptides in regions of the rat brain involved in the control of mood and motor control.

Place, publisher, year, edition, pages
Bentham Open , 2010. Vol. 3, 45-51 p.
Keyword [en]
Rat, brain, neuropeptides, estradiol, postpartum depression
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-58932DOI: 10.2174/1876528901003010045OAI: oai:DiVA.org:liu-58932DiVA: diva2:346998
Note
Original Publication: Ann Josefsson, Elvar Theodorsson, Göran Berg, Gunilla Sydsjö and Susanne Hilke, Complex Biphasic Changes of Neuropeptide Concentrations in the Rat Limbic System During Pregnancy and Parturition, 2010, The Open Neuroendocrinology Journal, (3), 45-51. http://dx.doi.org/10.2174/1876528901003010045 Licensee: Bentham open http://www.bentham.org/ Available from: 2010-09-02 Created: 2010-09-02 Last updated: 2010-09-02

Open Access in DiVA

fulltext(276 kB)550 downloads
File information
File name FULLTEXT01.pdfFile size 276 kBChecksum SHA-512
817d3a45e808728156689fe42811ad33867263e51889e1cae126190bde8fe8f213336d49ea30d71c102b90817f7e6a2d9f7de4bf296ee5c3d68d168a1cc56953
Type fulltextMimetype application/pdf

Other links

Publisher's full text

Authority records BETA

Josefsson, AnnTheodorsson, ElvarBerg, GöranSydsjö, GunillaHilke, Susanne

Search in DiVA

By author/editor
Josefsson, AnnTheodorsson, ElvarBerg, GöranSydsjö, GunillaHilke, Susanne
By organisation
Obstetrics and gynecology Faculty of Health SciencesDepartment of Gynecology and Obstetrics in LinköpingClinical ChemistryDepartment of Clinical Chemistry
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
Total: 550 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

doi
urn-nbn

Altmetric score

doi
urn-nbn
Total: 277 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf