Rapid T1 quantification based on 3D phase sensitive inversion recovery
2010 (English)In: BMC Medical Imaging, ISSN 1471-2342, Vol. 10, no 19Article in journal (Refereed) Published
BACKGROUND: In Contrast Enhanced Magnetic Resonance Imaging fibrotic myocardium can be distinguished from healthy tissue using the difference in the longitudinal T1 relaxation after administration of Gadolinium, the so-called Late Gd Enhancement. The purpose of this work was to measure the myocardial absolute T1 post-Gd from a single breath-hold 3D Phase Sensitivity Inversion Recovery sequence (PSIR). Equations were derived to take the acquisition and saturation effects on the magnetization into account.
METHODS: The accuracy of the method was investigated on phantoms and using simulations. The method was applied to a group of patients with suspected myocardial infarction where the absolute difference in relaxation of healthy and fibrotic myocardium was measured at about 15 minutes post-contrast. The evolution of the absolute R1 relaxation rate (1/T1) over time after contrast injection was followed for one patient and compared to T1 mapping using Look-Locker. Based on the T1 maps synthetic LGE images were reconstructed and compared to the conventional LGE images.
RESULTS: The fitting algorithm is robust against variation in acquisition flip angle, the inversion delay time and cardiac arrhythmia. The observed relaxation rate of the myocardium is 1.2 s-1, increasing to 6 - 7 s-1 after contrast injection and decreasing to 2 - 2.5 s-1 for healthy myocardium and to 3.5 - 4 s-1 for fibrotic myocardium. Synthesized images based on the T1 maps correspond very well to actual LGE images.
CONCLUSIONS: The method provides a robust quantification of post-Gd T1 relaxation for a complete cardiac volume within a single breath-hold.
Place, publisher, year, edition, pages
2010. Vol. 10, no 19
National CategoryEngineering and Technology Medical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-59065DOI: 10.1186/1471-2342-10-19PubMedID: 20716333OAI: oai:DiVA.org:liu-59065DiVA: diva2:349750