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Trapping single molecules by dielectrophoresis
Fraunhofer Inst Biomed Engn.
Göteborg University and Chalmers University of Technology.
Göteborg University and Chalmers University of Technology.
Göteborg University and Chalmers University of Technology.ORCID iD: 0000-0001-6235-7038
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2005 (English)In: Physical Review Letters, ISSN 0031-9007, E-ISSN 1079-7114, Vol. 95, no 12Article in journal (Refereed) Published
Abstract [en]

We have trapped single protein molecules of R-phycoerythrin in an aqueous solution by an alternating electric field. A radio frequency voltage is applied to sharp nanoelectrodes and hence produces a strong electric field gradient. The resulting dielectrophoretic forces attract freely diffusing protein molecules. Trapping takes place at the electrode tips. Switching off the field immediately releases the molecules. The electric field distribution is computed, and from this the dielectrophoretic response of the molecules is calculated using a standard polarization model. The resulting forces are compared to the impact of Brownian motion. Finally, we discuss the experimental observations on the basis of the model calculations.

Place, publisher, year, edition, pages
American Physical Society , 2005. Vol. 95, no 12
National Category
Engineering and Technology
Identifiers
URN: urn:nbn:se:liu:diva-59225DOI: 10.1103/PhysRevLett.95.128102ISI: 000231908200063OAI: oai:DiVA.org:liu-59225DiVA: diva2:350091
Available from: 2010-09-10 Created: 2010-09-09 Last updated: 2017-12-12

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Willander, Magnus

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