liu.seSearch for publications in DiVA
Change search
ReferencesLink to record
Permanent link

Direct link
PINCH Protein Expression in Normal Endometrium, Atypical Endometrial Hyperplasia and Endometrioid Endometrial Carcinoma
Hebei Medical University.
Hebei Medical University.
Hebei Medical University.
Tangshan Gongren Hospital.
Show others and affiliations
2010 (English)In: CHEMOTHERAPY, ISSN 0009-3157, Vol. 56, no 4, 291-297 p.Article in journal (Refereed) Published
Abstract [en]

Background: Particularly interesting new cysteine-histidine rich protein ( PINCH), as an adapter protein of the LIM family for signal transduction in the integrin and growth factor pathway, is upregulated in the stroma of several common types of cancers and involved in promoting tumor progression. In the present study, we examined PINCH expression in normal endometrium, atypical endometrial hyperplasia and endometrioid carcinoma, and further studied the relationships of PINCH expression with clinicopathological variables in cancer patients. Methods: PINCH expression was examined by immunohistochemistry in 23 normal endometrial samples, 18 atypical endometrial hyperplasias and 48 endometrioid endometrial carcinomas. Results: The PINCH expression in the stroma of cancer (71%) was significantly increased compared to either normal endometrium (17%, p andlt; 0.0001) or atypical hyperplasia (39%, p = 0.017), along with 9 cancers that had stronger PINCH expressions at the invasive margin of the cancers compared to the inner cancers. PINCH expression in cancer was higher in the patients with hypertension (p = 0.041) and estrogen exposure time andgt;30 years (p = 0.021). On the other hand, PINCH expression was not related to menopausal status, gravid status, blood sugar/lipid, family background of cancer, histological grade, myometrial invasion, cervical involvement, lymph nodal metastases, growth pattern, estrogen and progestogen receptors (p andgt; 0.05). Conclusion: The results suggest that PINCH seems to play a role, presently unknown, in the tumorigenesis and development of endometrial cancer that merits further study.

Place, publisher, year, edition, pages
S. Karger AG , 2010. Vol. 56, no 4, 291-297 p.
Keyword [en]
PINCH, Endometrioid endometrial carcinoma, Atypical hyperplasia, Immunohistochemistry
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-59266DOI: 10.1159/000319953ISI: 000281221100006OAI: diva2:350345
Original Publication: Hong-Zhen Zhang, Xue-Hui Li, Xia Zhang, Zhi-Yong Zhang, Ya-Li Meng, Shu-Wen Xu, Yan Zheng, Zhen-Long Zhu, Dong-Sheng Cui, Li-Xia Huang, Bao-Yong Yan and Xiao-Feng Sun, PINCH Protein Expression in Normal Endometrium, Atypical Endometrial Hyperplasia and Endometrioid Endometrial Carcinoma, 2010, CHEMOTHERAPY, (56), 4, 291-297. Copyright: S. Karger AG Available from: 2010-09-10 Created: 2010-09-10 Last updated: 2010-09-16

Open Access in DiVA

fulltext(516 kB)1157 downloads
File information
File name FULLTEXT01.pdfFile size 516 kBChecksum SHA-512
Type fulltextMimetype application/pdf

Other links

Publisher's full text

Search in DiVA

By author/editor
Sun, Xiao-Feng
By organisation
Oncology Faculty of Health SciencesDepartment of Oncology UHL
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
Total: 1157 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 41 hits
ReferencesLink to record
Permanent link

Direct link