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Prostaglandins and Radical Oxygen Species Are Involved in Microvascular Effects of Hyperoxia
Linköping University, Department of Medical and Health Sciences, Anesthesiology. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Sinnescentrum, Department of Anaesthesiology and Surgery UHL.
Linköping University, Department of Clinical and Experimental Medicine. Linköping University, Faculty of Health Sciences.
Linköping University, Department of Clinical and Experimental Medicine. Linköping University, Faculty of Health Sciences.
Linköping University, Department of Clinical and Experimental Medicine, Burn Center. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Sinnescentrum, Department of Plastic Surgery, Hand surgery UHL. Östergötlands Läns Landsting, Sinnescentrum, Department of Anaesthesiology and Surgery UHL.
2010 (English)In: JOURNAL OF VASCULAR RESEARCH, ISSN 1018-1172, Vol. 47, no 5, 441-450 p.Article in journal (Refereed) Published
Abstract [en]

Hyperoxia causes vasoconstriction in most tissues, by mechanisms that are not fully understood. We investigated microvascular effects of breathing 100% oxygen in healthy volunteers, using iontophoresis to deliver acetylcholine (ACh) and sodium nitroprusside (SNP). Aspirin and vitamin C were used to test for involvement of prostaglandins and radical oxygen species. Forearm skin perfusion was measured using laser Doppler perfusion imaging. Results were analysed using dose-response modelling. The response to ACh was reduced by 30% during oxygen breathing compared to air breathing [0.98 (0.81-1.15) PU vs. 1.45 (1.30-1.60) PU, p andlt; 0.001]. ED50 values were unchanged [2.25 (1.84-2.75) vs. 2.21 (1.79-2.74), not significant]. Aspirin pre-treatment abolished the difference in response between oxygen breathing and air breathing [maximum: 1.03 (0.90-1.16) vs. 0.89 (0.77-1.01), not significant; ED50: 1.83 (1.46-2.30) vs. 1.95 (1.65-2.30), not significant]. ACh-mediated vasodilatation during 100% oxygen breathing was partially restored after pre-treatment with vitamin C. Breathing 100% oxygen did not change the microvascular response to SNP [1.45 (1.28-1.62) vs. 1.40 (1.26-1.53), not significant]. These results favour the hypothesis that hyperoxic vasoconstriction is mediated by inhibition of prostaglandin synthesis. Radical oxygen species may be involved as vitamin C, independently of aspirin, partially restored ACh-mediated vasodilatation during hyperoxia.

Place, publisher, year, edition, pages
S. Karger AG , 2010. Vol. 47, no 5, 441-450 p.
Keyword [en]
Acetylcholine, Perfusion, Hyperoxia, Iontophoresis, Prostaglandins, Radical oxygen species, Sodium nitroprusside
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-59256DOI: 10.1159/000282667ISI: 000281228100007OAI: oai:DiVA.org:liu-59256DiVA: diva2:350372
Note
Original Publication: Andreas Rousseau, Erik Tesselaar, Joakim Henricson and Folke Sjöberg, Prostaglandins and Radical Oxygen Species Are Involved in Microvascular Effects of Hyperoxia, 2010, JOURNAL OF VASCULAR RESEARCH, (47), 5, 441-450. http://dx.doi.org/10.1159/000282667 Copyright: S. Karger AG http://www.karger.com/ Available from: 2010-09-10 Created: 2010-09-10 Last updated: 2012-03-20

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AnesthesiologyFaculty of Health SciencesDepartment of Anaesthesiology and Surgery UHLDepartment of Clinical and Experimental MedicineBurn CenterDepartment of Plastic Surgery, Hand surgery UHL
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