liu.seSearch for publications in DiVA
Change search
ReferencesLink to record
Permanent link

Direct link
Increased ATP-binding cassette transporter A1 expression in Alzheimer's disease hippocampal neurons
Prince of Wales Medical Research Institute, Randwick NSW, Australia; School of Medical Sciences, Faculty of Medicine, University of New South Wales, Sydney NSW, Australia.
Prince of Wales Medical Research Institute, Randwick NSW, Australia.
Prince of Wales Medical Research Institute, Randwick NSW, Australia.
Linköping University, Department of Clinical and Experimental Medicine, Geriatric . Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Local Health Care Services in the East of Östergötland, Department of Geriatrics. (Prince of Wales Medical Research Institute, Randwick NSW, Australia)
Show others and affiliations
2010 (English)In: Journal of Alzheimer's disease : JAD, ISSN 1875-8908, Vol. 21, no 1, 193-205 p.Article in journal (Refereed) Published
Abstract [en]

ATP-binding cassette transporter A1 (ABCA1) reduces amyloid-beta burden in transgenic mouse models of Alzheimer's disease (AD). Associations between ABCA1 polymorphisms and AD risk are also established. Little is known regarding the regulation of ABCA1 expression in the brain and how this may be affected by AD. In the present study we assessed ABCA1 mRNA and protein expression in the hippocampus of AD cases compared to controls. ABCA1 was clearly expressed in hippocampal neurons and expression was increased two- to three-fold in AD cases. The increased hippocampal ABCA1 expression was associated with increased APOE and PUMA gene expression, implying an association with neuronal stress. Consistent with this, treatment of SK-N-SH neurons with amyloid-beta peptide resulted in a 48% loss in survival and a significant upregulation of ABCA1, APOE, and PUMA gene expression. Studies in young (2 month) and old (12 month) transgenic mice expressing a familial AD form of human amyloid-beta protein precursor and presenilin-1 revealed a significant age-dependent upregulation of hippocampal Abca1 compared to wild-type control mice. However, hippocampal Apoe and Puma gene expression were not correlated with increased Abca1 expression in mice. Our data indicate that ABCA1 is upregulated in AD hippocampal neurons potentially via an amyloid-beta-mediated pathway.

Place, publisher, year, edition, pages
2010. Vol. 21, no 1, 193-205 p.
Keyword [en]
ABCA1, Alzheimer's disease, amyloid-β peptide, ATP-binding cassette transporter A1, hippocampus, neurodegeneration
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-59485DOI: 10.3233/JAD-2010-100324PubMedID: 20413849OAI: diva2:351888
Available from: 2010-09-16 Created: 2010-09-16 Last updated: 2010-09-17

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Agholme, LottaKågedal, Katarina
By organisation
Geriatric Faculty of Health SciencesDepartment of GeriatricsExperimental Pathology
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 66 hits
ReferencesLink to record
Permanent link

Direct link