liu.seSearch for publications in DiVA
Change search
ReferencesLink to record
Permanent link

Direct link
Immunological Effects of TBE Vaccination: Increased Expression of Transcription factor T-bet Indicates Activation of Th1-like Cellular Immunity
Linköping University, Faculty of Health Sciences, Engelska: Faculty of Health Sciences, Medical Programme.
2007 (English)Independent thesis Advanced level (professional degree), 15 credits / 22,5 HE creditsStudent thesis
Abstract [en]

Tick-borne encephalitis virus is the cause of much morbidity and sometimes a fatal infection. A vaccine based on formaldehyde inactivated virus is currently the only available way of preventing disease. This vaccine gives a high rate of seroconversion but there are reports of vaccination breakthrough, even in people who have demonstrated a neutralizing antibody response. The T cell response to inactivated TBE vaccine is largely unknown, but could be of importance for the effect of the vaccine. This study characterizes aspects of the T cell response by investigating the expression of two transcription factors, T-bet and GATA-3 with RT-PCR. T-bet is expressed in CD4+ T cells of the Th1 type, while GATA-3 is expressed in CD4+ T cells of the Th2 type. Our data show that vaccination with inactivated TBE vaccine leads to increase in expression of the T-bet gene when cells of vaccinated subjects are cultured with TBE virus. In contrast, the expression of GATA-3 remains unaffected by vaccination. Thus, this study suggests that the inactivated TBE vaccine leads to a Th1-like immune response in humans.

Place, publisher, year, edition, pages
2007. , 24 p.
Keyword [sv]
TBE, Vaccination, T-cell, T-bet, GATA-3, Th1, Th2
National Category
Immunology in the medical area
URN: urn:nbn:se:liu:diva-59537ISRN: -OAI: diva2:352209
Available from: 2011-03-01 Created: 2010-09-19 Last updated: 2011-03-04Bibliographically approved

Open Access in DiVA

fulltext(450 kB)400 downloads
File information
File name FULLTEXT01.pdfFile size 450 kBChecksum SHA-512
Type fulltextMimetype application/pdf

Search in DiVA

By author/editor
Andersson, Pär
By organisation
Engelska: Faculty of Health Sciences, Medical Programme
Immunology in the medical area

Search outside of DiVA

GoogleGoogle Scholar
Total: 400 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Total: 303 hits
ReferencesLink to record
Permanent link

Direct link