Letter: Atrial fibrillation and platelet reactivity: in International Journal of Cardiology(ISSN 0167-5273)(EISSN 1874-1754)
2010 (English)In: International Journal of Cardiology, ISSN 0167-5273, E-ISSN 1874-1754, Vol. 145, no 2, 357-358 p.Article in journal, Letter (Other academic) Published
BACKGROUND: The impact of atrial fibrillation (AF) upon platelet reactivity has not been investigated.
METHODS: Subjects were 33 individuals with AF who consented to elective electrical cardioversion (ECV) immediately before ECV determination of surface-bound fibrinogen after stimulation i.e. platelet reactivity was carried out. A flow cytometer was employed. ADP (1.7 and 8.5mumol/L) and a thrombin receptor activating peptide (54 and 74mumol/L) were used as agonists. The analyses were repeated after 26+/-8(SD) months.
RESULTS: Compared to day 1 subjects with AF (n=18) had a trend towards lower platelet reactivity at study end. It reached significance when using 1.7mumol/L ADP. In contrast, after 26+/-8(SD) months sinus rhythm (SR) (n=15) was associated with significant lower reactivity with all agonists.
CONCLUSION: After 26+/-8(SD) months patients returning with AF had higher platelet reactivity than those who remained with SR.
Place, publisher, year, edition, pages
Ireland: Elsevier , 2010. Vol. 145, no 2, 357-358 p.
Atrial fibrillation, Flow cytometry, platelet reactivity, platelet activity
Cardiac and Cardiovascular Systems
IdentifiersURN: urn:nbn:se:liu:diva-59612DOI: 10.1016/j.ijcard.2010.02.030OAI: oai:DiVA.org:liu-59612DiVA: diva2:352638
Original Publication: Micha Milovanovic, Elisabeth Fransson, Claes Hallert and Petter Järemo, Letter: Atrial fibrillation and platelet reactivity, International Journal of Cardiology, 2010. http://dx.doi.org/10.1016/j.ijcard.2010.02.030 Copyright: Elsevier2010-09-292010-09-212012-06-29Bibliographically approved