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Function of the Drosophila CPEB protein Orb2 in long-term courtship memory
Research Institute of Molecular Pathology, Vienna.
Research Institute of Molecular Pathology, Vienna.
Research Institute of Molecular Pathology, Vienna.
Research Institute of Molecular Pathology, Vienna.
2007 (English)In: Nature Neuroscience, ISSN 1097-6256, E-ISSN 1546-1726, Vol. 10, no 12, 1587-1593 p.Article in journal (Refereed) Published
Abstract [en]

Both long-term behavioral memory and synaptic plasticity require protein synthesis, some of which may occur locally at specific synapses. Cytoplasmic polyadenylation element-binding (CPEB) proteins are thought to contribute to the local protein synthesis that underlies long-term changes in synaptic efficacy, but a role has not been established for them in the formation of long-term behavioral memory. We found that the Drosophila melanogaster CPEB protein Orb2 is acutely required for long-term conditioning of male courtship behavior. Deletion of the N-terminal glutamine-rich region of Orb2 resulted in flies that were impaired in their ability to form long-term, but not short-term, memory. Memory was restored by expressing Orb2 selectively in fruitless (fru)positive c neurons of the mushroom bodies and by providing Orb2 function in mushroom bodies only during and shortly after training. Our data thus demonstrate that a CPEB protein is important in long-term memory and map the molecular, spatial and temporal requirements for its function in memory formation.

Place, publisher, year, edition, pages
Nature Publishing Group , 2007. Vol. 10, no 12, 1587-1593 p.
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-59693DOI: 10.1038/nn1996ISI: 000251172900016OAI: oai:DiVA.org:liu-59693DiVA: diva2:353013
Available from: 2010-09-23 Created: 2010-09-23 Last updated: 2017-12-12

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Alenius, Mattias

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