Direct glucocorticoid receptor-Stat5 interaction in hepatocytes controls body size and maturation-related gene expression
2007 (English)In: Genes & Development, ISSN 0890-9369, E-ISSN 1549-5477, Vol. 21, no 10, 1157-1162 p.Article in journal (Refereed) Published
The glucocorticoid receptor regulates transcription through DNA binding as well as through cross-talk with other transcription factors. In hepatocytes, the glucocorticoid receptor is critical for normal postnatal growth. Using hepatocyte- specific and domain-selective mutations in the mouse we show that Stat5 in hepatocytes is essential for normal postnatal growth and that it mediates the growth- promoting effect of the glucocorticoid receptor through a direct interaction involving the N-terminal tetramerization domain of Stat5b. This interaction mediates a selective and unexpectedly extensive part of the transcriptional actions of these molecules since it controls the expression of gene sets involved in growth and sexual maturation.
Place, publisher, year, edition, pages
Csh Cold Spring Harbor Laboratory Press , 2007. Vol. 21, no 10, 1157-1162 p.
somatomedin; liver; Cre-loxP; growth hormone; microarray
National CategoryMedical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-59690DOI: 10.1101/gad.426007ISI: 000246531800004OAI: oai:DiVA.org:liu-59690DiVA: diva2:353067