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Addition of a macrolide to a beta-lactam in bacteremic pneumococcal pneumonia
Karolinska University Hospital.
Karolinska University Hospital.
Karolinska University Hospital.
Swedish Institute for Infectious Disease Control.
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2006 (English)In: European Journal of Clinical Microbiology and Infectious Diseases, ISSN 0934-9723, E-ISSN 1435-4373, Vol. 25, no 8, 518-521 p.Article in journal (Refereed) Published
Abstract [en]

In the study presented here, data collected prospectively from 340 adult patients hospitalised in five countries with bacteremic pneumococcal CAP and treated with a beta-lactam +/- a macrolide were analysed retrospectively to evaluate the efficacy of this antimicrobial combination. Univariate and multivariate analyses revealed no significant effect on case fatality rate when a macrolide/beta-lactam regimen was used as initial therapy. Results were not affected by severity of illness, or by excluding patients who died within 2 days of admission. Identified predictors of death in a multivariate regression model were age greater than 65 years (OR=2.6), two or more lung lobes affected (OR=2.2), and severity of disease as estimated using the acute physiology score (APS)greater than 8.

Place, publisher, year, edition, pages
Springer Science Business Media , 2006. Vol. 25, no 8, 518-521 p.
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Medical and Health Sciences
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URN: urn:nbn:se:liu:diva-59687DOI: 10.1007/s10096-006-0183-2ISI: 000239813400006OAI: oai:DiVA.org:liu-59687DiVA: diva2:353072
Available from: 2010-09-23 Created: 2010-09-23 Last updated: 2017-12-12

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