liu.seSearch for publications in DiVA
Change search
ReferencesLink to record
Permanent link

Direct link
The Lim homeobox gene Lhx2 is required for olfactory sensory neuron identity
Umeå University.
Umeå University.
Umeå University.
Umeå University.
2004 (English)In: Development, ISSN 0950-1991, E-ISSN 1477-9129, Vol. 131, no 21, 5319-5326 p.Article in journal (Refereed) Published
Abstract [en]

Progenitor cells in the mouse olfactory epithelium generate over a thousand subpopulations of neurons, each expressing a unique odorant receptor (OR) gene. This event is under the control of spatial cues, since neurons in different epithelial regions are restricted to express region-specific subsets of OR genes. We show that progenitors and neurons express the LIM-homeobox gene Lhx2 and that neurons in Lhx2-null mutant embryos do not diversify into subpopullations expressing different OR genes and other region-restricted genes such as Nqo1 and Ncam2. Lhx2(-/-)embryos have, however, a normal distribution of Mashlpositive and neurogenin 1-positive neuronal progenitors that leave the cell cycle, acquire pan-neuronal traits and form axon bundles. Increased cell death in combination with increased expression of the early differentiation marker Neurod1, as well as reduced expression of late differentiation markers (Galphaolf and Omp), suggests that neuronal differentiation in the absence of Lhx2 is primarily inhibited at, or immediate prior to, onset of OR expression. Aberrant regional expression of early and late differentiation markers, taken together with unaltered region-restricted expression of the Msx1 homeobox gene in the progenitor cell layer of Lhx2-1- embryos, shows that Lhx2 function is not required for all aspects of regional specification of progenitors and neurons. Thus, these results indicate that a cell-autonomous function of Lhx2 is required for differentiation of progenitors into a heterogeneous population of individually and regionally specified mature olfactory sensory neurons.

Place, publisher, year, edition, pages
Company of Biologists Ltd , 2004. Vol. 131, no 21, 5319-5326 p.
Keyword [en]
Lhx2; neurod1; olfactory; gene expression; odorant receptors; LIM; homeobox; neuron; differentiation; mouse
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-59674DOI: 10.1242/dev.01416ISI: 000225422200011PubMedID: 15456728OAI: diva2:353091
Available from: 2010-09-23 Created: 2010-09-23 Last updated: 2010-09-24

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Alenius, Mattias
In the same journal
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 26 hits
ReferencesLink to record
Permanent link

Direct link