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A genetic cascade involving klumpfuss, nab and castor specifies the abdominal leucokinergic neurons in the Drosophila CNS
University Autonoma of Madrid.
University Autonoma of Madrid.
University Autonoma of Madrid.
Linköping University, Faculty of Health Sciences. Linköping University, Department of Clinical and Experimental Medicine, Developmental Biology, IKE.
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2010 (English)In: DEVELOPMENT, ISSN 0950-1991, Vol. 137, no 19, 3327-3336 p.Article in journal (Refereed) Published
Abstract [en]

Identification of the genetic mechanisms underlying the specification of large numbers of different neuronal cell fates from limited numbers of progenitor cells is at the forefront of developmental neurobiology. In Drosophila, the identities of the different neuronal progenitor cells, the neuroblasts, are specified by a combination of spatial cues. These cues are integrated with temporal competence transitions within each neuroblast to give rise to a specific repertoire of cell types within each lineage. However, the nature of this integration is poorly understood. To begin addressing this issue, we analyze the specification of a small set of peptidergic cells: the abdominal leucokinergic neurons. We identify the progenitors of these neurons, the temporal window in which they are specified and the influence of the Notch signaling pathway on their specification. We also show that the products of the genes klumpfuss, nab and castor play important roles in their specification via a genetic cascade.

Place, publisher, year, edition, pages
Company of Biologists Ltd , 2010. Vol. 137, no 19, 3327-3336 p.
Keyword [en]
Drosophila, CNS development, Neuronal fate specification, Leucokinin, ABLK
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-59724DOI: 10.1242/dev.052233ISI: 000281608200018OAI: diva2:353175
Available from: 2010-09-24 Created: 2010-09-24 Last updated: 2010-09-24

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Baumgardt, MagnusThor, Stefan
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