liu.seSearch for publications in DiVA
Change search
ReferencesLink to record
Permanent link

Direct link
Non-genomic effects of androgens on isolated human vascular and nonvascular penile erectile tissue
Hannover Medical School.
Hannover Medical School.
von Baldersche Stiftung, Giessen.
Private Practice of Dermatology, Hannover.
Show others and affiliations
2008 (English)In: BJU International, ISSN 1464-4096, E-ISSN 1464-410X, Vol. 101, no 1, 71-75 p.Article in journal (Refereed) Published
Abstract [en]

OBJECTIVES: To evaluate non-genomic effects of testosterone and dihydrotestosterone (DHT) on isolated human cavernosal arteries (HCA) and corpus cavernosum (HCC) using organ-bath studies and radio-immunoassays (RIA), as non-genomic effects of androgens are reported for vascular smooth musculature and there is evidence that the relaxant response involves a modulation of cyclic nucleotide tissue levels.

MATERIALS AND METHODS: The relaxation induced by the cumulative addition of testosterone and DHT (0.01-10 microm) was studied using circular segments of HCA and strip preparations of HCC. To evaluate the effects of testosterone and DHT on tissue levels of cAMP and cGMP, specimens were exposed to increasing concentrations of the hormones. Forskolin and sodium nitroprusside (SNP) served as reference compounds.

RESULTS: Testosterone and DHT dose-dependently reversed the noradrenaline-induced tension of vascular segments and HCC strips. At the maximum concentration, testosterone and DHT reduced the mean (sd) tension to 79.8 (4.43)% and 83.9 (10.94)%, respectively. SNP and forskolin significantly stimulated the production of cGMP and cAMP. No effects of testosterone and DHT on cGMP and cAMP levels were detected.

CONCLUSION: Rapid androgen-induced relaxation of HCA and HCC occurs via non-genomic mechanisms. In penile erectile tissue, non-genomic relaxant effects of testosterone and DHT are not mediated via modulation of cyclic nucleotide tissue levels. Additional studies are required to establish if non-genomic relaxant effects are important in ensuring a basal level of perfusion to maintain overall penile function.

Place, publisher, year, edition, pages
Blackwell Publishing Ltd , 2008. Vol. 101, no 1, 71-75 p.
Keyword [en]
cavernosal arteries;corpus cavernosum;dihydrotestosterone;hypogonadism;testosterone;non-genomic effects
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-59812DOI: 10.1111/j.1464-410X.2007.07182.xISI: 251503000015PubMedID: 17868421OAI: diva2:353319
Available from: 2010-09-25 Created: 2010-09-24 Last updated: 2011-08-17

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Hedlund, Petter
By organisation
Clinical PharmacologyFaculty of Health Sciences
In the same journal
BJU International
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 24 hits
ReferencesLink to record
Permanent link

Direct link