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Longitudinal scintigraphic study of parotid and submandibular gland function after total body irradiation in children and adolescents
Östergötlands Läns Landsting, Public Dental Service, Centre for Orthodontics and Paediatric Dentistry.
Huddinge University Hospital.
Huddinge University Hospital.
Karolinska Institute.
2007 (English)In: International Journal of Paediatric Dentistry, ISSN 0960-7439, E-ISSN 1365-263X, Vol. 17, no 1, 34-40 p.Article in journal (Refereed) Published
Abstract [en]

Objective. Total body irradiation (TBI) and cyclophosphamide (CY) during allogeneic stem cell transplantation (ASCT) cause salivary gland dysfunction in children. The aim of this investigation was to study the scintigraphic functional changes over time of the parotid and submandibular glands in children and young adults one year after treatment with CY and TBI at ASCT Methods. Salivary gland scintigraphy (SGS) was performed before ASCT, and 3-6 months and 12 months after ASCT. The three male patients who fulfilled the scintigraphic study had a mean age (+/- SD) of 17.3 +/- 9.8 years at ASCT Results. The parotid secretion capacity (SPar) was 83.5 +/- 3.2% before ASCT and 48.5 +/- 25.8% during the next 3-6 months (P less than 0.05). The SPar did not increase (48.1 +/- 12.4%) during the rest of the first year after ASCT. The submandibular emptying capacity (SSub) was 91.3 +/- 12.9% before ASCT and 35.4 +/- 2.3% after 3-6 months (P less than 0.05). The SSub was 87.9 +/- 17.9% one year after ASCT Conclusions. The parotid glands were more sensitive to irradiation since they did not recover lost capacity to secrete saliva, while the submandibular glands recovered the secretion capacity at the one year follow-up

Place, publisher, year, edition, pages
Blackwell Publishing Ltd. , 2007. Vol. 17, no 1, 34-40 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-59809DOI: 10.1111/j.1365-263X.2006.00786.xISI: 244190400006PubMedID: 17181577OAI: diva2:353322
Available from: 2010-09-25 Created: 2010-09-24 Last updated: 2010-10-28

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