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Heat shock protein 72/73 in relation to cytoplasmic p53 expression and prognosis in colorectal adenocarcinomas
Linköping University, Department of Clinical and Experimental Medicine, Oncology . Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Centre of Surgery and Oncology, Department of Oncology UHL.
Linköping University, Department of Clinical and Experimental Medicine, Dermatology and Venerology . Linköping University, Faculty of Health Sciences.
Linköping University, Department of Medicine and Health Sciences, Health and Society. Linköping University, Faculty of Arts and Sciences.
Linköping University, Department of Clinical and Experimental Medicine, Oncology . Linköping University, Faculty of Health Sciences.
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1997 (English)In: International Journal of Cancer, ISSN 0020-7136, E-ISSN 1097-0215, Vol. 74, no 6, 600-604 p.Article in journal (Refereed) Published
Abstract [en]

Heat shock proteins (hsp) are molecular chaperones that are increased by various environmental and patho-physiological stimuli. Hsp can bind to mutant/wild-type p53 in tumors and, consequently, could not only regulate p53 accumulation or localization but also modulate its biological effects on cells. However, there is little information available on the significance of hsp expression in colorectal cancer. The aim of our study was to investigate the relationship of hsp to p53 expression, clinico-pathological factors and prognosis in a series of 256 patients with colorectal adenocarcinomas, using immuno-histochemistry. Seventy-five cases exhibited hsp expression in the cytoplasm, with 11 presenting both cytoplasmic and nuclear staining. Hsp expression was related positively to cytoplasmic p53 expression but not to nuclear p53 expression. In the subgroup of rectal tumors, hsp over-expression appeared to predict unfavorable survival, though its prognostic value diminished using multivariate analysis. There were no significant relationships of hsp with patient sex or age, tumor site, Duke's stage, growth pattern or differentiation.

Place, publisher, year, edition, pages
John Wiley and Sons, Ltd , 1997. Vol. 74, no 6, 600-604 p.
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Medical and Health Sciences
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URN: urn:nbn:se:liu:diva-59763DOI: 10.1002/(SICI)1097-0215(19971219)74:6<600::AID-IJC7>3.0.CO;2-YISI: 71194500007PubMedID: 9421355OAI: oai:DiVA.org:liu-59763DiVA: diva2:353390
Available from: 2010-09-27 Created: 2010-09-24 Last updated: 2017-12-12

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Sun, Xiao-FengZhang, HongCarstensen, JohnJansson, AgnetaNordenskjöld, Bo

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Oncology Faculty of Health SciencesDepartment of Oncology UHLDermatology and Venerology Health and SocietyFaculty of Arts and Sciences
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International Journal of Cancer
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