Modelling the activation, opening, inactivation and reopening of the voltage-gated sodium channel
1998 (English)In: Proceedings of the Royal Society of London. Biological Sciences, ISSN 0962-8452, E-ISSN 1471-2954, Vol. 265, no 1393, 263-270 p.Article in journal (Refereed) Published
A model of the voltage-gated sodium channel is put forward suggesting that the four S4 voltage-sensors behave as screw-helices making a series of discrete transitions that carry one elementary charge for each notch of the screw helix. After the channel has been activated by the first two steps R reversible arrow P reversible arrow A in all four domains, followed by a voltage-independent rearrangement, it is opened by a third cooperative step A reversible arrow B in domains I, II and III in conjunction with hydration. Inactivation is a voltage-dependent process controlled by the third step A reversible arrow I in sensor IVS4, and the closing of the channel is brought about its dehydration. From the inactivated steady state the channel may be reopened by a fourth step, I reversible arrow C in sensor IVS4 and rehydration. The computed kinetics of the model are shown to conform closely with those observed experimentally.
Place, publisher, year, edition, pages
Royal Society , 1998. Vol. 265, no 1393, 263-270 p.
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-59757DOI: 10.1098/rspb.1998.0291ISI: 72112800002OAI: oai:DiVA.org:liu-59757DiVA: diva2:353396