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On the slowly rising phase of the sodium gating current in the squid giant axon
University of Cambridge.
Karolinska Institute.
1998 (English)In: Proceedings of the Royal Society of London. Biological Sciences, ISSN 0962-8452, E-ISSN 1471-2954, Vol. 265, no 1393, 255-262 p.Article in journal (Refereed) Published
Abstract [en]

High-resolution records of the sodium gating current in the squid giant axon demonstrate the existence of a slowly rising phase that is first apparent at pulse potentials slightly below zero, and becomes increasingly pronounced at more positive potentials. At +80 mV the current reaches its peak with a delay of 30 mu s at 10 degrees C. It is suggested that this current is generated by the first two steps labelled R--greater thanP and P--greater thanA in the S4 units of all four domains of the series-parallel gating system, activating the channel before its opening by the third steps A--greater thanB in domains I, II and III in conjunction with hydration. The kinetics of the slowly rising phase can only be explained by the incorporation of an appropriate degree of voltage-dependent cooperativity between the S4 voltage-sensors for their two initial transitions.

Place, publisher, year, edition, pages
Royal Society , 1998. Vol. 265, no 1393, 255-262 p.
National Category
Engineering and Technology
Identifiers
URN: urn:nbn:se:liu:diva-59755ISI: 72112800001OAI: oai:DiVA.org:liu-59755DiVA: diva2:353398
Available from: 2010-09-27 Created: 2010-09-24 Last updated: 2017-12-12

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Elinder, Fredrik

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