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The one-person randomized controlled trial
Swedish Association of Local Authorities and Regions, Stockholm.
Linköping University, Department of Mechanical Engineering, Quality Technology and Management. Linköping University, The Institute of Technology.
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2005 (English)In: Quality Management in Health Care, ISSN 1063-8628, E-ISSN 1550-5154, Vol. 14, no 4, 206-216 p.Article in journal (Refereed) Published
Abstract [en]

Currently, the gold standard for collection of clinical evidence is the randomized controlled trial (RCT), preferably with large, multicenter samples of subjects. Although this approach provides valuable information, many clinicians find it difficult to translate RCT results to the individual patient level. In this report, a statistical approach called Design of Experiments (DOE) is described as a method of applying the principles of RCTs one person at a time. An overview of the method, with a simple clinical example, is presented. As shown, DOE is a more efficient method than the sequential approach often taken by clinicians and their patients when evaluating various treatment choices. Further, the effect of multiple interventions can be assessed, alone or in combination with each other. In this way, DOE can be an important addition to the field of evidence-based medicine, although further studies are needed.

Place, publisher, year, edition, pages
2005. Vol. 14, no 4, 206-216 p.
National Category
Engineering and Technology
URN: urn:nbn:se:liu:diva-60036PubMedID: 16227864OAI: diva2:354766
Available from: 2010-10-04 Created: 2010-10-04 Last updated: 2010-10-19

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Elg, Mattias
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Quality Technology and ManagementThe Institute of Technology
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