Strain based estimation of time dependent transmural myocardial architecture in the ovine heart
2010 (English)In: Biomechanics and Modeling in Mechanobiology, ISSN 1617-7959, E-ISSN 1617-7940, Vol. 10, no 4, 521-528 p.Article in journal (Refereed) Published
Left ventricular myofibers are connected by an extensive extracellular collagen matrix to form myolaminar sheets. Histological cardiac tissue studies have previously observed a pleated transmural distribution of sheets in the ovine heart, alternating sign of the sheet angle from epicardium to endocardium. The present study investigated temporal variations in myocardial fiber and sheet architecture during the cardiac cycle. End diastolic histological measurements made at subepicardium, midwall and subendocardium at an anterior-basal and a lateral-equatorial region of the ovine heart, combined with transmural myocardial Lagrangian strains, showed that the sheet angle but not the fiber angle varied temporally throughout the cardiac cycle. The magnitude of the sheet angle decreased during systole at all transmural depths at the anterior-basal site and at midwall and subendocardium depths at the lateral-equatorial site, making the sheets more parallel to the radial axis. These results support a previously suggested accordion-like wall thickening mechanism of the myocardial sheets.
Place, publisher, year, edition, pages
SpringerLink , 2010. Vol. 10, no 4, 521-528 p.
Cardiac mechanics; transmural; sheets; wall thickening; myocardium
Engineering and Technology
IdentifiersURN: urn:nbn:se:liu:diva-60199DOI: 10.1007/s10237-010-0252-4PubMedID: 20821245OAI: oai:DiVA.org:liu-60199DiVA: diva2:355631