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SALIVARY ALPHA-AMYLASE IN A POPULATION BASED SAMPLE. ASSOCIATIONS WITH PSYCHOSOCIAL FACTORS, SELF RATED HEALTH AND INFLAMMATORY MARKERS
Linköping University, Department of Medical and Health Sciences, Social Medicine and Public Health Science. Linköping University, Faculty of Health Sciences.
Linköping University, Department of Physics, Chemistry and Biology, Applied Physics. Linköping University, The Institute of Technology.
Linköping University, Department of Medical and Health Sciences, Social Medicine and Public Health Science. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Centre for Public Health Sciences.
Linköping University, Department of Physics, Chemistry and Biology, Applied Physics. Linköping University, The Institute of Technology.
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2010 (English)In: International Journal of Behavioral Medicine, ISSN 1070-5503, E-ISSN 1532-7558, Vol. 17, no 1 Supplement, S181-S181 p.Article in journal, Meeting abstract (Other academic) Published
Abstract [en]

Objective: In recent years, salivary alpha-amylase (sAA) has beenproposed as a reliable proxy for sympathetic activity. This study aimed at testing the association between sAA to a broad range of psychosocial factors, self rated health, cardiovascular risk factors and inflammatory markers in a normal population sample.

Methods: 30 participants, all men between 50 and 54 years old, were randomly selected from a normal population based study. Saliva samples were collected at awakening, 30 minutes after awakening and just before going to bed. sAA was measured by a calorimetric method using Phadebas amylase test. Linear regression models were used to test associations between sAA levels and a broad spectrum of psychosocial factors (e.g. depressive symptamology, vital exhaustion, mastery and sense of coherence) self rated health and inflammatory markers (e.g. C-reactive protein). Adjustments were made for physical exercise, smoking, blood  lipids and  time point  when  sample was collected.

Results: sAA levels at awakening were positively associated with depressive symptamology (p = 0.046), vital exhaustion (p = 0.025) and negatively associated with sense of coherence (p = 0.034). It was further associated positively associated with levels of C-reactive protein (p = 0.024)  and  negatively associated with  self  reported general health (p = 0.010). Samples taken just before going to bed were showing similar results, whereas samples taken 30 minutes after awakening only showed a few significant associations.

Conclusions: The associations found give further support for the use of salivary alpha amylase as a psychoneuroendocrinological bio- marker. Assessment just after awakening or just before going to bed seems to be more reliable than samples 30 minutes after awakening.

Place, publisher, year, edition, pages
Springer-Verlag New York, 2010. Vol. 17, no 1 Supplement, S181-S181 p.
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Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-60240DOI: 10.1007/s12529-010-9106-9ISI: 000280088500418OAI: oai:DiVA.org:liu-60240DiVA: diva2:355856
Conference
11th International Congress of Behavioral Medicine, "Translational Behavioural Research: A Global Challenge.", Washington DC, USA, August 04 - 07, 2010
Available from: 2010-10-08 Created: 2010-10-08 Last updated: 2017-12-12Bibliographically approved

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Garvin, PeterSuska, AnkeKristenson, MargaretaLundström, IngemarErnerudh, Jan

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Garvin, PeterSuska, AnkeKristenson, MargaretaLundström, IngemarErnerudh, Jan
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Social Medicine and Public Health ScienceFaculty of Health SciencesApplied PhysicsThe Institute of TechnologyCentre for Public Health SciencesClinical ImmunologyDepartment of Clinical Immunology and Transfusion Medicine
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