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Prevalence of fecal carriage of antibiotic-resistant bacteria in patients with acute surgical abdominal infections
Uppsala University.
Linköping University, Department of Clinical and Experimental Medicine, Clinical Microbiology . Linköping University, Faculty of Health Sciences.
Uppsala University.
Uppsala University.
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2010 (English)In: SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY, ISSN 0036-5521, Vol. 45, no 10, 1203-1210 p.Article in journal (Refereed) Published
Abstract [en]

Objective. Antibiotic resistance is increasing worldwide. The aims of the current study were to determine the fecal carriage of antibiotic-resistant bacteria and antibiotic treatment in surgical patients admitted to hospital due to acute intra-abdominal infections. Materials and methods. Eight Swedish surgical units participated in this prospective multicenter investigation. Rectal swabs were obtained on admission to hospital. Cultures were performed on chromogenic agar and antibiotic susceptibility testing was performed using the disk diffusion method. Extended-spectrum beta-lactamase (ESBL)phenotype was confirmed by Etest. Results. Rectal samples were obtained and analyzed from 208 patients with intra-abdominal surgical infections. Surgery was performed in 134 patients (65%). Cephalosporins were the most frequently used empirical antibiotic therapy. The highest rates of resistance among Enterobacteriaceae were detected for ampicillin (54%), tetracycline (26%), cefuroxime (26%) and trimethoprim-sulfamethoxazole (20%). The prevalence of decreased susceptibility (I + R) for the other antibiotics tested was for ciprofloxacin 20%, piperacillin-tazobactam 17%, cefotaxime 14%, ertapenem 12%, gentamicin 3% and imipenem 0%. ESBL-producing Enterobacteriaceae were found in samples from 10 patients (5%). Three patients had five E. coli isolates producing AmpC enzymes. Conclusions. This study shows a high rate of resistance among Enterobacteriaceae against antibiotics which are commonly used in Sweden and should have implications for the future choice of antibiotics for surgical patients.

Place, publisher, year, edition, pages
Informa Healthcare , 2010. Vol. 45, no 10, 1203-1210 p.
Keyword [en]
Abdominal infection, antibiotics, antibiotic resistance, bacteria, resistance
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-60498DOI: 10.3109/00365521.2010.495417ISI: 000282151500010PubMedID: 20521871OAI: diva2:357062
Available from: 2010-10-15 Created: 2010-10-15 Last updated: 2010-11-15

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Tärnberg, MariaNilsson, LennartLindberg, ChristianHanberger, Håkan
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Clinical Microbiology Faculty of Health SciencesInfectious Diseases Department of Infectious Diseases in Östergötland
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