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Electrochemical synthesis of electroactive polymers for drugrelease for bio scaffolds.
Linköping University, Department of Physics, Chemistry and Biology.
2010 (English)Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
Abstract [en]

Stem cell based therapy has the potential to treat several severe diseases; Parkinson’s

disease is one well- known example. Transplantation of stem cell derived cells into

animal models is unfortunately often associated with tumour formation or- uncontrolled

growth of the transplanted cells. One strategy to suppress this tumour formation might be

to induce differentiation of these cells, which in turn would prevent them from dividing.

 

Neuroblastoma tumors are known to demonstrate the complete transition from an

undifferentiated state to a completely harmful, differentiated appearance and derived cells

can be used as a model for cell differentiation and tumor suppression.

 

In this Master Thesis’s the conducting polymers PEDOT and PPy, that upon formation

can be doped with biologically active compounds which in- turn can be released in a

controlled manner through electrical stimulation, were formed together with various

drugs (e.g. Methotrexate and Mycophenolic Acid), here shown to have effect on

Neuroblastoma cells. Neuroblastoma- derived cell line SH- SY5Y was used as a model

system for neuronal differentiation and tumour inhibition. Release profiles of

neuroblastoma active drugs following electrical stimulation were evaluated and the

effects from electrochemical processes on simultaneously growing SH- SY5Y cells were

investigated.

 

The methods to deposit and release the drugs were based on electropolymerization and

electrochemically controlled release, respectively. Controlled release of various drugs

and compounds was monitored using Vis- and UV- spectroscopy and on some occasions

using HPLC.

 

The electrochemically controlled release of a biologically inactive compound that can be

used as a negative control for electrochemical release in future experiments was shown

and that resulting electrochemical processes have negative effects on neuroblastoma cell

growth.

Place, publisher, year, edition, pages
2010. , 71 p.
Keyword [en]
Electrochemically Controlled Drug Release, Medical Devices, Conducting Polymers
National Category
Other Industrial Biotechnology
Identifiers
URN: urn:nbn:se:liu:diva-60570ISRN: LITH-IFM-A-EX-10/2280- SEOAI: oai:DiVA.org:liu-60570DiVA: diva2:357955
Uppsok
Physics, Chemistry, Mathematics
Supervisors
Examiners
Available from: 2010-10-26 Created: 2010-10-20 Last updated: 2010-10-26Bibliographically approved

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Other Industrial Biotechnology

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CiteExportLink to record
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Citation style
  • apa
  • harvard1
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  • modern-language-association-8th-edition
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Language
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Output format
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