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Spectroscopic method for determination of the absorption coefficient in brain tissue
Linköping University, Department of Biomedical Engineering, Biomedical Instrumentation. Linköping University, The Institute of Technology. (MINT)
2010 (English)In: Journal of Biomedical Optics, ISSN 1083-3668, E-ISSN 1560-2281, Vol. 15, no 5, 057005-1-057005-9 p.Article in journal (Refereed) Published
Abstract [en]

I use MonteCarlo simulations and phantom measurements to characterize a probe withadjacent optical fibres for diffuse reflectance spectroscopy during stereotactic surgeryin the brain. Simulations and measurements have been fitted toa modified Beer–Lambert model for light transport in order tobe able to quantify chromophore content based on clinically measuredspectra in brain tissue. It was found that it isimportant to take the impact of the light absorption intoaccount when calculating the apparent optical path length, lp, forthe photons in order to get good estimates of theabsorption coefficient, µa. The optical path length was found tobe well fitted to the equation lp=a+b ln(Is)+c ln(µa)+d ln(Is)ln(µa), where Is isthe reflected light intensity for scattering alone (i.e., zero absorption).Although coefficients ad calculated in this study are specific tothe probe used here, the general form of the equationshould be applicable to similar probes.

Place, publisher, year, edition, pages
Society of Photo-optical Instrumentation Engineers , 2010. Vol. 15, no 5, 057005-1-057005-9 p.
Keyword [en]
diffuse reflectance spectroscopy; brain; Monte Carlo simulations; chromophore quantification
National Category
Medical Laboratory and Measurements Technologies
Identifiers
URN: urn:nbn:se:liu:diva-60798DOI: 10.1117/1.3495719ISI: 000284837400049OAI: oai:DiVA.org:liu-60798DiVA: diva2:359198
Available from: 2010-10-27 Created: 2010-10-27 Last updated: 2017-02-09Bibliographically approved

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Johansson, Johannes

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